Evidence map›Paper›PMID 40823827›Full record

ArticlemBio2025

Disrupting NtrC function reveals unexpected robustness in a central cell cycle regulatory network.

Hunter North, Molly Hydorn, Jonathan Dworkin, Aretha Fiebig, Sean Crosson

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. TheJournal of bacteriology · 2026
    Article
  3. Suppressor analysis inFrontiers in microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hunter NorthDepartment of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, Michigan, USA.
Molly HydornDepartment of Microbiology and Immunology, Columbia University, New York, New York, USA.
Jonathan DworkinDepartment of Microbiology and Immunology, Columbia University, New York, New York, USA.ORCID 0000-0002-8205-6918
Aretha FiebigDepartment of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-0612-5029
Sean CrossonDepartment of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-1727-322X

Funding

Molecular mechanisms controlling stress responses and cell adhesion in bacteriaR35GM131762 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Sean Crosson · 2019 to 2026
$3.2M
Regulation of quiescence in bacteriaR35GM141953 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jonathan Dworkin · 2021 to 2026
$2.5M
NIGMS NIH HHS R35 GM131762NIGMS NIH HHS R35 GM141953NIH HHS R35GM131762
6 · The paper itself

Abstract

Cell cycle progression relies on coordinated signaling systems that integrate diverse cellular and environmental cues. In

Indexed as

Bacterial ProteinsCaulobacterCaulobacter crescentusCell CycleGene Expression Regulation, BacterialTranscription FactorsDNA-Binding ProteinsGlutamineHistidine KinaseMutationSignal TransductionBacterial ProteinsCtrA protein, CaulobacterDNA-Binding ProteinsGlutamineHistidine KinaseTranscription Factorsbacterial enhancer binding proteinCaulobacterevolutionRNA polymerasesigma factorsignal transduction

Identifiers

PMID40823827
PMCPMC12421884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.