Evidence map›Paper›PMID 40823825›Full record

ArticlemBio2025

Matrix-independent screening of defluorination

Anitha T Simon, Anthony G Dodge, Julie Bondy, Madeline R O'Connor, Alptekin Aksan, Lawrence P Wackett

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anitha T SimonDepartment of Mechanical Engineering, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.ORCID 0009-0003-5838-8052
Anthony G DodgeBiotechnology Institute, University of Minnesota Twin Cities, Saint Paul, Minnesota, USA.ORCID 0009-0003-6136-9880
Julie BondyBiotechnology Institute, University of Minnesota Twin Cities, Saint Paul, Minnesota, USA.ORCID 0009-0005-6164-7558
Madeline R O'ConnorBiotechnology Institute, University of Minnesota Twin Cities, Saint Paul, Minnesota, USA.ORCID 0009-0007-4419-3050
Alptekin AksanDepartment of Mechanical Engineering, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
Lawrence P WackettBiotechnology Institute, University of Minnesota Twin Cities, Saint Paul, Minnesota, USA.ORCID 0000-0002-3255-1101

Funding

National Science Foundation 2343831
6 · The paper itself

Abstract

There is intense interest in biodegrading fluorinated pesticides and other commercial products, some of which are per- and poly-fluorinated alkyl substances, or PFAS. Enzymatic carbon-fluorine bond cleavage via hydrolytic, reductive, and eliminative mechanisms generates an organic product, fluoride anion, and a proton. Biodegradation is typically determined by tracking the organic product using liquid chromatography-mass spectrometry (LC-MS) or the anion determined by a fluoride-specific electrode. Here, we monitored the protons that are produced. A pH indicator method was developed using a hydrolytic defluorinase from

Indexed as

Bacterial ProteinsDelftia acidovoransFluorocarbonsHydrolasesPesticidesBiodegradation, EnvironmentalElectrodesFluoridesHalogenationLiquid Chromatography-Mass SpectrometryPseudomonas putidaRecombinant ProteinsSubstrate SpecificityBacterial ProteinsFluoridesfluoroacetate-specific dehalogenaseFluorocarbonsHydrolasesPesticidesRecombinant Proteinsagar platesbacteriadefluorinationenzymehydrogelliquid mediaPFASpH indicatorrapid methodscreening

Identifiers

PMID40823825
PMCPMC12421806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.