Evidence map›Paper›PMID 40823821›Full record

ArticlemBio2025

Trigeminal TRPV1 regulates pneumococcal nose-to-brain invasion via IL-6/TNF-α signals.

Hideki Sakatani, Masamitsu Kono, Masayoshi Hijiya, Yohei Morita, Tomoko Sumitomo, Tatsuya Inukai, Shigeki Nakamura, Yusuke Koizumi, Kenta Maruyama, Shizuya Saika and 2 more

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hideki Sakatani *Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.ORCID 0009-0003-1995-9174
Masamitsu Kono *Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Masayoshi HijiyaDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Yohei MoritaDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Tomoko SumitomoDepartment of Oral Microbiology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID 0000-0003-0653-0339
Tatsuya InukaiDepartment of Microbiology, Tokyo Medical University, Tokyo, Japan.
Shigeki NakamuraDepartment of Microbiology, Tokyo Medical University, Tokyo, Japan.ORCID 0000-0001-5272-8886
Yusuke KoizumiDepartment of Infection Prevention and Control, Wakayama Medical University, Wakayama, Japan.
Kenta MaruyamaDepartment of Pharmacology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan.
Shizuya SaikaDepartment of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
Masaaki MurakamiDivision of Molecular Psychoimmunology, Hokkaido University, Institute for Genetic Medicine and Graduate School of Medicine, Sapporo, Japan.
Muneki HotomiDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.ORCID 0000-0003-4705-5319

Funding

Japan Society for the Promotion of Science 22K08585Japan Society for the Promotion of Science 22K10492Japan Society for the Promotion of Science 23K08992Japan Society for the Promotion of Science 25K02792Morinomiyako Medical Research Foundation 2024-01-009Shionogi & Co. Ltd. 2024N086Takeda Science Foundation 2022040637
6 · The paper itself

Abstract

The nasal cavity acts as a gateway through which pathogens can invade the human body.

Indexed as

BrainInterleukin-6Pneumococcal InfectionsStreptococcus pneumoniaeTrigeminal NerveTRPV Cation ChannelsTumor Necrosis Factor-alphaAnimalsDisease Models, AnimalFemaleMiceMice, Inbred C57BLSignal TransductionInterleukin-6TRPV1 protein, mouseTRPV Cation ChannelsTumor Necrosis Factor-alphahost-pathogen interactionsinvasive microorganismsnose-to-brain infectionpneumococcusTRPV1

Identifiers

PMID40823821
PMCPMC12421820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.