Evidence map›Paper›PMID 40823816›Full record

ArticleAntimicrobial agents and chemotherapy2025

Piperacillin reaches high concentrations in bile and target tissues of the biliary system: an experimental study in pigs.

Louise L Pontoppidan, Mats Bue, Kim C Houlind, Anders R Knudsen, Jan B Pedersen, Magnus A Hvistendahl, Pelle Hanberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pharmacokinetics of Piperacillin in an Experimental Porcine Liver Model During Normothermic Machine Perfusion.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Louise L PontoppidanDepartment of Surgery, Lillebaelt Hospital, Kolding, Denmark.ORCID 0000-0001-6110-8427
Mats BueDepartment of Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-7215-8323
Kim C HoulindDepartment of Regional Health Research, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-1600-4415
Anders R KnudsenDepartment of Surgery, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-5630-8317
Jan B PedersenDepartment of Surgery, Aalborg University Hospital, Aalborg, Denmark.
Magnus A HvistendahlAarhus Denmark Microdialysis Research Group (ADMIRE), Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-4086-0238
Pelle HanbergAarhus Denmark Microdialysis Research Group (ADMIRE), Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-6845-1874

Funding

Grosserer LF Foghts Fond No grand ID was providedKnud og Edith Eriksens Mindefond (KEE MEMORIAL FUND) No grand ID was providedLizzi og Mogens Staal Fonden No grand ID was providedThe Research Council, Lillebaelt Hospital No grand ID was provided
6 · The paper itself

Abstract

The antibiotic combination of piperacillin/tazobactam (TZP) is commonly utilized for preventing and treating infections in the biliary system, with piperacillin being the primary agent. Its effectiveness is closely related to the time with concentrations above the minimal inhibitory concentration (

Indexed as

Anti-Bacterial AgentsBileBiliary TractPiperacillinAnimalsCommon Bile DuctGallbladderLiverMicrobial Sensitivity TestsMicrodialysisPenicillanic AcidPiperacillin, Tazobactam Drug CombinationSwineAnti-Bacterial AgentsPenicillanic AcidPiperacillinPiperacillin, Tazobactam Drug Combinationanimal modelbiliary systemmicrodialysispharmacokineticspiperacillin/tazobactam

Identifiers

PMID40823816
PMCPMC12486830

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.