ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
POSTN-Mediated Interplay of M1 Polarized Macrophage with Tendon-Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Nano-layered tendon patch to orchestrate timely interactions between tendon stem/progenitor cells and macrophages.Biomaterials · 2027Article
- Modulation of innate and adaptive immunity by pH-responsive nanozyme-like nanoparticles with high mobility for rheumatoid arthritis alleviation.Bioactive materials · 2026Article
- Tendon stem/progenitor cells in heterotopic ossification: functional regulation, molecular mechanisms and targeted therapeutic strategies.Journal of orthopaedic translation · 2026Review
- On-demand mild photothermal cascade platform reprogramming mitochondrial immunity for tendon rejuvenation.Bioactive materials · 2026Article
- Integrated bioinformatic analysis of biomarkers, pathways, and immune cell infiltration in ossification of the ligamentum flavum.International journal of clinical and experimental pathology · 2026Article
- Single cell RNA-seq analysis associates Osm signaling in macrophages with osteogenic differentiation during heterotopic ossification.Journal of orthopaedic surgery and research · 2025Article
- POSTN-Mediated Interplay of M1 Polarized Macrophage with Tendon-Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mitochondrial Transplantation: A Paradigm Shift in Osteoporosis Therapy.International journal of nanomedicine · 2025Review
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Authors and funding
10 authors.
Funding
Abstract
Tendinous heterotopic ossification can cause pain and restricted joint mobility in affected areas, and it is a common and severe complication following tendon injuries. This condition significantly reduces the postoperative quality of life of patients, and its incidence is increasing year by year. Due to the unclear pathogenesis, there are currently no effective treatment methods. Although recent studies suggest that macrophages affect the process of traumatic heterotopic ossification (HO) in mice, their role in HO still requires further clarification. Here, it is disclosed that the formation of trauma-induced HO is accompanied by the polarization of macrophages toward the M1 phenotype. Additionally, secretion containing periostin (POSTN) that is secreted by M1 macrophages reduces fatty acid β - oxidation in tendon-derived stem cells (TDSCs) and facilitates the formation of heterotopic bone. Mechanistically, M1 macrophages release POSTN during the HO process, which directly binds to PTK7 in TDSCs, thereby increasing AKT phosphorylation at the S124 site and initiating osteogenic differentiation. This study demonstrates the role of M1 macrophages and their secreted POSTN in traumatic heterotopic ossification, highlighting the potential of POSTN as a therapeutic target for HO.
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