Evidence map›Paper›PMID 40823739›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

An Automated Micro-Immunobeads-Based Electromagnetic Operation System (MEMOs) for Blood Testing of Alzheimer's Disease.

Xiaoxue Fan, Xinyu Ye, Jiangrui Xu, Tianjiao Mao, Ruotong Zhang, Xinyuan Zhou, Christina C K Au Yeung, Chang Li, Raymond Chuen-Chung Chang, Haisong Lin and 1 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoxue FanDepartment of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, 000000, China.ORCID https://orcid.org/0009-0002-1760-3302
Xinyu YeLaboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Laboratory Block, Rm. L4-49, 21 Sassoon Road, Pokfulam, Hong Kong SAR, 000000, China.
Jiangrui XuSchool of Engineering, Westlake University, 600 Dunyu Road, Hangzhou, Zhejiang, 310030, China.
Tianjiao MaoDepartment of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, 000000, China.
Ruotong ZhangDepartment of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, 000000, China.
Xinyuan ZhouSchool of Engineering, Westlake University, 600 Dunyu Road, Hangzhou, Zhejiang, 310030, China.
Christina C K Au YeungDepartment of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, 000000, China.
Chang LiAdvanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, New Territories, Hong Kong SAR, 000000, China.
Raymond Chuen-Chung ChangLaboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Laboratory Block, Rm. L4-49, 21 Sassoon Road, Pokfulam, Hong Kong SAR, 000000, China.
Haisong LinDepartment of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, 000000, China.
Ho Cheung ShumDepartment of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, 000000, China.ORCID https://orcid.org/0000-0002-6365-8825

Funding

Bingei and L & T Charitable Foundation Professorship in Dementia ResearchCollaborative Research Fund C7165-20GFGeneral Research Fund 17208623General Research Fund 17306221General Research Fund 17317322NSFC Young Scientists Fund 32201181RGC Senior Research Fellow SRFS2425-7S04the Health@InnoHK program of the Innovation and Technology Commission of the Hong Kong SAR Government
6 · The paper itself

Abstract

The anticipated rise in the prevalence of Alzheimer's disease (AD) under global demographic shifts necessitates the development of universally accessible screening and diagnostic tools, of which blood tests hold the promise. However, the widespread adoption of blood tests remains impeded by the lack of analytically validated biomarkers and accessible decentralized platforms. Here, the study presents a portable and automated micro-immunobeads-based electromagnetic operation system, termed MEMOs, targeting potential AD blood biomarker exosome-bound Aβ42 (Exo-Aβ42), for automated blood testing of AD. MEMOs integrates a microfluidic exosome-detection biological chip (μ-Exo Biochip) embedded with a magnetic field-responsive assay for detecting Exo-Aβ42 and a microbead operation electromagnetic chip (μ-Bead EMchip) for programmable and addressable actuation, collectively delivering a high level of accurate and automated AD testing. In both animal and clinical samples, the levels of Exo-Aβ42 measured using MEMOs have shown significant correlations with various progressive stages of AD. With the features of cost-effective manufacturing, minimized hands-on time, and an easy operation workflow, MEMOs offers an accessible pathway toward diagnosing and monitoring the progression of AD in decentralized practice.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsBiomarkersExosomesHumansMiceAmyloid beta-PeptidesBiomarkersautomationdiagnosiselectromagneticmicrofluidicspoint‐of‐care

Identifiers

PMID40823739
PMCPMC12591217

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.