Evidence map›Paper›PMID 40823706›Full record

ArticleAIDS care2025

Oral health and behavioral problems in children living with and without HIV in South Africa.

Ana Barrios-Tascon, Tian Wang, Renate Strehlau, Nicole H Tobin, Avy Violari, Fan Li, Faeezah Patel, Afaaf Liberty, Stephanie Shiau, Sunil Wadhwa and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ana Barrios-TasconGertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Tian WangDepartment of Biostatistics, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA.
Renate StrehlauVIDA Nkanyezi Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Nicole H TobinDepartment of Pediatrics, University of California Los Angeles, Los Angeles, CA, USA.
Avy ViolariPerinatal HIV Research Unit, Chris Hani Baragwanath Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Fan LiDepartment of Pediatrics, University of California Los Angeles, Los Angeles, CA, USA.
Faeezah PatelWits RHI, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Afaaf LibertyPerinatal HIV Research Unit, Chris Hani Baragwanath Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Stephanie ShiauDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA.
Sunil WadhwaCollege of Dental Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Michael T YinDivision of Infectious Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Shuang WangDepartment of Biostatistics, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA.
Caroline T TiemessenNational Institutes for Communicable Diseases, Johannesburg, South Africa.
Grace M AldrovandiDepartment of Pediatrics, University of California Los Angeles, Los Angeles, CA, USA.
Louise KuhnGertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.

Funding

Host epigenetic and mitochondrial function in HIV-infected childrenR01HD073952 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2012 to 2016
$3.7M
Bone health in perinatally HIV-infected South African children on antiretroviralsR01HD073977 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARPADI, STEPHEN M, YIN, MICHAEL T · 2012 to 2016
$3.6M
Treatment Options for Protease Inhibitor Exposed ChildrenR01HD061255 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2010 to 2014
$2.9M
Clinical Relevance of Transient Nevirapine ResistanceR01HD047177 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2004 to 2008
$2.6M
Oral microbial signatures in perinatal HIV infectionR01DE028135 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2018 to 2021
$2.5M
NICHD NIH HHS R01 HD047177NICHD NIH HHS R01 HD061255NICHD NIH HHS R01 HD073952NICHD NIH HHS R01 HD073977NIDCR NIH HHS R01 DE028135
6 · The paper itself

Abstract

The prevalence of behavioral problems in children and adolescents living with HIV is high. We investigate associations between oral microbiota and behavioral problems in children living with HIV (CLWH) and children who are HIV-uninfected (CHU). Oral swab samples, assessment of behavioral functioning using the Strengths and Difficulties Questionnaire (SDQ), and clinical and social data were collected from 477 CLWH and 123 CHU at two sites in Johannesburg, South Africa. DNA was extracted from oral swab samples and the V4 amplicon of the 16S rRNA gene sequenced. Behavioral problems were more prevalent in CLWH than in CHU, and in boys than in girls. Oral microbiota diversity and taxa abundances in CLWH did not differ between those with and without behavioral problems. In contrast, in CHU, those with behavioral problems had higher alpha diversity indices and lower abundances of

Indexed as

Child Behavior DisordersHIV InfectionsOral HealthProblem BehaviorAdolescentChildChild, PreschoolDental CariesFemaleHumansMaleMicrobiotaPrevalenceRNA, Ribosomal, 16SSouth AfricaSurveys and QuestionnairesRNA, Ribosomal, 16Sbehavioral problemsChildren with HIVGood health and well beingmicrobiomeoral swabquality educationSouth Africa

Identifiers

PMID40823706
PMCPMC12461875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.