ArticleCNS neuroscience & therapeutics2025
IL-4-JAK1-STAT6 Pathway Mediates Electroacupuncture's Effect on Microglial M2 Polarization to Treat Inflammatory Bowel Disease With Comorbid Depression.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mechanism-Driven Translation of Electroacupuncture for Depression: Bridging the Gap Between Preclinical and Clinical Research.Neuropsychiatric disease and treatment · 2026Review
- Acupuncture's Regulatory Role in Glial Cells and Their Interactions for Antidepressant Effects: A Review of Research Progress.Journal of multidisciplinary healthcare · 2026Review
- Depression and Gastrointestinal Health Abnormalities: Treatment Approaches from the Perspective of Traditional Chinese Medicine.Neuropsychiatric disease and treatment · 2026Review
- Neurobiological Correlates of Coping Strategies in PTSD: The Role of IGF-1, CASP-9, nNOS, and IL-10 Based on Brief-COPE Assessment.Current issues in molecular biology · 2025Article
- IL-4-JAK1-STAT6 Pathway Mediates Electroacupuncture's Effect on Microglial M2 Polarization to Treat Inflammatory Bowel Disease With Comorbid Depression.CNS neuroscience & therapeutics · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
aimsDepression is prevalent in inflammatory bowel disease (IBD) and linked to neuroinflammation. However, the underlying mechanisms remain unclear. Therefore, we investigated the efficacy of electroacupuncture in mice with IBD and depression.
methodsAn IBD mouse model of depression was established using 2.0% dextran sodium sulfate (DSS). After electroacupuncture, general condition and behavior were evaluated. Colon morphology was observed using hematoxylin and eosin staining. Serum inflammatory factors were detected using enzyme-linked immunosorbent assay. Microglial activation was measured using immunofluorescence. Hippocampal protein expression was assessed using Western blotting and real-time fluorescence quantitative polymerase chain reaction.
resultsDSS-induced model mice exhibited significant depression-like behaviors and colon pathology. Serum and colon IL-1β expression was elevated (p < 0.01), while IL-4, IL-10, and TGF-β1 expression was decreased (p < 0.01 or p < 0.05). Hippocampal microglial activation was evident, with increased IL-1β expression (p < 0.01) and reduced IL-4, IL-10, TGF-β1, JAK1, STAT6, and p-STAT6 expression (p < 0.01 or p < 0.05). Electroacupuncture resolved these changes; though its effects were significantly weakened after IL-4 and p-STAT6 inhibitor administration (p < 0.01 or p < 0.05). Transcriptomic sequencing of hippocampal tissue indicates that pro-inflammatory pathways such as TNF/NF-κB/mTOR are activated in the model group. Electroacupuncture can activate the IL-4-mediated JAK-STAT signaling pathway, inhibit the activation of pro-inflammatory signaling pathways, upregulate neuroprotective genes such as Slc2a3, Mef2d, and Jak1, and exert anti-inflammatory effects.
conclusionIL-4-JAK1-STAT6 signaling may be an important pathway in mediating the efficacy of electroacupuncture in IBD with comorbid depression, particularly promoting microglial M2 polarization and improving neuroinflammation.
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