Evidence map›Paper›PMID 40823663›Full record

ArticleBlood neoplasia2025

Developmental stage and cellular context determine oncogenic and molecular outcomes of

Sarah M Zimmerman, Samantha J Procasky, Sofia R Smith, Jie-Yu Liu, Chad Torrice, George P Souroullas

Abstract read
In one paragraph

Article in Blood neoplasia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Sarah M ZimmermanDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO.
Samantha J ProcaskyDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO.
Sofia R SmithDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO.
Jie-Yu LiuDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Chad TorriceDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
George P SouroullasDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the histone methyltransferase enhancer of zeste homolog 2 (EZH2), particularly the neomorphic Y641F hot spot mutation, are implicated in hematologic malignancies. However, how developmental timing and cellular context influence their oncogenic potential remains poorly understood. Here, we used a conditional

Identifiers

PMID40823663
PMCPMC12356278

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.