Evidence map›Paper›PMID 40823590›Full record

ArticleFrontiers in medicine2025

Dysregulated tRNA-derived fragments impair fatty acid metabolism in intrahepatic cholestasis of pregnancy.

Lian Yang, Xia Yu, Shimao Zhang, Jinzhu Fu, Mengjun Luo, Wei Shen, Cheng Huang, Xiao Yang

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PubMed Full text at PMC Publisher
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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lian YangDepartment of Clinical Laboratory, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xia YuDepartment of Clinical Laboratory, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Shimao ZhangDepartment of Obstetrics, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Jinzhu FuDepartment of Obstetrics, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Mengjun LuoDepartment of Clinical Laboratory, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Wei ShenDepartment of Clinical Laboratory, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Cheng HuangDepartment of Clinical Laboratory, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xiao YangDepartment of Obstetrics, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Intrahepatic cholestasis of pregnancy (ICP) is a common obstetric complication that occurs predominantly in the mid-to-late gestational period, but its exact etiology remains unclear. Recent studies have revealed that transfer RNA-derived fragments (tRFs) are closely associated with various diseases; however, whether tRFs contribute to ICP pathogenesis remains unknown. This study was designed with the objectives of investigating the expression profiles of tRFs in patients with ICP, exploring the potential correlation between tRF expression and maternal-fetal pathophysiological changes, identifying novel early diagnostic biomarkers, and ultimately enhancing clinical management strategies. Methods: Serum samples were collected from 3 ICP patients and 3 healthy controls before delivery. Small RNA sequencing was performed via the Illumina platform, and the obtained sequences were aligned and screened against the tRFdb database to identify differentially expressed tRFs. Potential target genes of tRFs were predicted, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses to assess their functional implications. Results: Compared with controls, ICP patients presented significant differential expression of 5 tRFs, including 2 upregulated tRFs and 3 downregulated tRFs, in prenatal serum. Furthermore, GO and KEGG analyses suggested that fatty acid degradation might be associated with 3003a_trf-3 and 3005b_trf-3. Conclusion: This study provides preliminary data for the validation of serum-based biomarkers in ICP patients. The findings suggest that tRF dysregulation may be involved in ICP pathogenesis via the fatty acid degradation pathway, offering new molecular insights and a foundation for the development of early intervention strategies to prevent adverse fetal outcomes. These conclusions require further validation in larger sample cohorts.

Indexed as

fatty acidintrahepatic cholestasis of pregnancy (ICP)total bile acid (TBA)tRNA-derived fragments (tRFs)tRNA-derived small RNAs (tsRNAs)

Identifiers

PMID40823590
PMCPMC12351929

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.