ArticleFrontiers in medicine2025
The predictive value of D-dimer combined with systemic immune-inflammation index for the presence of pulmonary thromboembolism in AECOPD patients.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to evaluate the predictive potential of D-dimer levels and the systemic immune-inflammatory index (SII) for identifying concurrent pulmonary thromboembolism (PTE) in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Methods: We conducted a case-control study involving 75 patients with AECOPD and concurrent PTE, admitted to the Affiliated Hospital of Guangdong Medical University between June 2017 and December 2020. A control group comprising 76 AECOPD patients without PTE was included for comparison. Clinical characteristics and laboratory findings were compared between the two groups. Multivariate logistic regression was employed to identify independent risk factors for PTE in AECOPD patients. The predictive accuracy of these risk factors was assessed using receiver operating characteristic (ROC) curves, while Spearman correlation analysis evaluated associations between variables. Model robustness was validated internally using bootstrap techniques, and decision curve analysis (DCA) was applied to determine the clinical utility of the predictive model. Results: Multivariate logistic regression identified D-dimer [odds ratio (OR) 1.17, 95% confidence interval (CI) 1.03-1.38] and the SII (OR 1.003, 95% CI 1.000-1.006) as independent risk factors for PTE in patients with AECOPD. The area under the ROC curve (AUC) values for predicting PTE in AECOPD patients were 0.758 (95% CI 0.682-0.834) for D-dimer, 0.757 (95% CI 0.677-0.838) for SII, and 0.834 (95% CI 0.768-0.900) for their combination, respectively. The Bootstrap results demonstrated that the model combining D-dimer and SII had an AUC of 0.8409 (95% CI: 0.7649, 0.9156), indicating robust performance across resampled datasets. Both D-dimer and SII showed a positive correlation with hospital stay duration ( Conclusion: D-dimer and SII are independent risk factors for predicting concurrent PTE in AECOPD patients. The combination of these two markers demonstrates robust predictive accuracy, and their levels may be positively correlated with disease severity. These findings suggest that D-dimer and SII could play a valuable role in clinical decision-making and risk stratification in AECOPD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.