SynthesisFrontiers in medicine2025
Nurse-led weaning protocols-a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Research has demonstrated that protocol-directed weaning shortens the duration of mechanical ventilation (MV). Nurse-led weaning protocols have also been suggested to reduce MV duration in patients. Nevertheless, their implementation in mechanically ventilated patients is not widespread, and their clinical effectiveness remains uncertain. Aim: This study aimed to evaluate the effectiveness of nurse-led weaning protocols compared to physician-led weaning in mechanically ventilated patients. Methods: Eleven electronic databases (PubMed, Embase, Cochrane Library, CINAHL, EBSCO, Scopus, Web of Science, Sino Med, CNKI, VIP, and Wanfang) were systematically searched from their inception to January 20, 2024. Two researchers conducted a literature search and data extraction independently. We performed all statistical analyses using RevMan 5.1. The certainty of evidence was assessed using the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) profiler Guideline Development Tool. Results: Our analysis included a total of six relevant studies. The analysis of pooled data revealed that nurse-led weaning protocols were associated with a significant reduction in the duration of MV (MD = -1.78 days, 95% confidence interval (CI) = -3.08 to -0.48, I Conclusion: Current evidence indicates that nurse-led weaning protocols have the potential to decrease the duration of MV, ICU LOS, LOS, and incidence of VAP in mechanically ventilated patients. However, these findings should be interpreted with caution due to the moderate-to-low quality of evidence and the limited number of available studies. Further high-quality, large-scale research is needed to confirm the effectiveness and safety of nurse-led weaning protocols in diverse clinical settings. Systematic review registration: Identifier: CRD42023487455, https://www.crd.york.ac.uk/prospero.
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Registered trials
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