ArticleFrontiers in medicine2025
The global burden of osteoarthritis hand: lessons from the Global Burden of Disease Study 1990-2021.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- PIEZO1 variants that reduce open channel probability are associated with familial osteoarthritis.The Journal of biological chemistry · 2026Article
- The association between social determinants, lifestyle, and metabolic factors and the incidence of hand osteoarthritis: A cohort study of British adults.Clinical rheumatology · 2026Article
- Mitochondrial-targeted therapy for osteoarthritis: Challenges and opportunities from basic research to clinical translation.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hand osteoarthritis (HOA), a disabling musculoskeletal disorder, poses a significant global burden but remains understudied relative to other osteoarthritis (OA) subtypes. Using data from the Global Burden of Disease (GBD) Study 1990-2021, this analysis characterizes HOA epidemiology, temporal trends, and future projections. Methods: GBD 2021 data on HOA incidence, prevalence, and disability-adjusted life-years (DALYs) were stratified by sex, age, Socio-demographic Index (SDI) regions, GBD regions, and countries. Temporal trends (1990-2021) were assessed via estimated annual percentage changes (EAPCs), with future projections (2022-2046) generated using an age-period-cohort (APC) model. Results: In 2021, HOA accounted for 10.37 million incidence cases, 194.28 million prevalence cases, and 6.17 million DALYs. Female burdens were 1.8-2.0 times higher than males in absolute terms and 1.75-1.78 times higher in age-standardized rates (ASRs). Incidence cases peaked in advanced ages before declining, while prevalence/DALYs rose monotonically with age. Middle SDI regions had the highest absolute burdens, whereas high SDI regions showed the highest ASRs. Central Asia emerged as a burden hotspot, while minimal health system regions and sub-Saharan Africa had the lowest rates. From 1990 to 2021, global incidences increased 142%. Low/middle-income regions (such as South Asia) saw significant increases, contrasting with declines in high-income areas (such as Western Europe). APC projections indicate continued growth through 2046, with male/female incidences rising 69.6%/51.6% and ASRs increasing for both sexes. Conclusion: HOA represents a growing global challenge with pronounced sex/age/regional disparities. Targeted interventions in high-burden regions, aging populations, and risk factor management are critical to mitigate projected burden increases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.