Evidence map›Paper›PMID 40823559›Full record

ReviewFrontiers in medicine2025

Probiotics in inflammatory bowel diseases: emphasis on mechanisms and clinical application.

Junxiang Zhang, Xiaoman Zhang, Xiaoxin Cheng, Shijin Wang, Yangxuan Lv, Xu Zheng, Guangzhen Wu

Abstract readReview
In one paragraph

Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Anti-Inflammatory Potential ofMicroorganisms · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. The interplay between probiotics and mast cells in gut inflammation: a mini-review.Frontiers in cellular and infection microbiology · 2026
    Review
  7. Review
  8. Review
  9. Polydopamine-chitosan coated biofilm-stateMaterials today. Bio · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Junxiang Zhang *Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Xiaoman Zhang *Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Xiaoxin ChengDepartment of Cell Biology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Shijin WangDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Yangxuan LvDepartment of Cell Biology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Xu ZhengDepartment of Cell Biology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Guangzhen WuDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a group of diseases characterized by chronic intestinal inflammation including Crohn's disease (CD) and ulcerative colitis (UC). In recent years, probiotics have attracted more and more attention as a potential adjuvant therapy. Probiotics can improve the symptoms and quality of life of IBD patients mainly by regulating intestinal microflora, regulating immune response, enhancing intestinal barrier function and exerting anti-inflammatory effect. However, although a large number of studies have explored the role of probiotics, there are still individual differences and uncertainties in clinical application. This paper reviews the mechanism, clinical effect and future prospect of probiotics in the treatment of IBD, and analyzes the existing clinical research and experimental data to provide reference for further research. Finally, this paper looks forward to the research direction of probiotics in the treatment of IBD, aiming at providing evidence for clinical practice.

Indexed as

Crohn’s diseasegut microbiotainflammatory bowel diseaseprobioticsulcerative colitis

Identifiers

PMID40823559
PMCPMC12355611

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.