ArticleJournal of Taibah University Medical Sciences2025
Preemptive analgesia regimen modulates hippocampal
Article in Journal of Taibah University Medical Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: The study evaluated morphologically Methods: Sixty female Sprague-Dawley rats, weighing 150-250 g and 8-10 weeks of age, were included in this laboratory-based experimental study at Khyber Medical University, Peshawar, over approximately 2 years, from January 2022 to January 2024. The rats were divided into a superficial pain group and a deep pain group. Each group was further subdivided into tramadol, buprenorphine, and saline subgroups. Isoflurane general anesthesia was administered. Pain was assessed with a subjective pain scale (Abdominal Pain Assessment, APA) at 2, 4, 6, 9, and 24 h post-surgery. Expression of c-fos in hippocampal tissue, including the dentate gyrus, CA1, and CA3 regions, was detected immunohistochemically. Results: Postoperative administration of a preemptive regimen comprising either buprenorphine or tramadol significantly ( Conclusion: Postoperative pain was significantly diminished in animal models with use of a preemptive regimen. This regimen not only decreased pain transmission but also ameliorated emotional distress in the animals.
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