Evidence map›Paper›PMID 40823415›Full record

ArticleFrontiers in psychology2025

Eleonora Mascheroni, Fabiana Mambretti, Laura Cordolcini, Annalisa Castagna, Elisa Rosa, Niccolò Butti, Andrea Citterio, Nivedita Agarwal, Rosario Montirosso

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eleonora MascheroniScientific Institute, IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Italy.
Fabiana MambrettiScientific Institute, IRCCS E. Medea, Molecular Biology Lab, Bosisio Parini, Italy.
Laura CordolciniScientific Institute, IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Italy.
Annalisa CastagnaScientific Institute, IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Italy.
Elisa RosaScientific Institute, IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Italy.
Niccolò ButtiScientific Institute, IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Italy.
Andrea CitterioScientific Institute, IRCCS E. Medea, Molecular Biology Lab, Bosisio Parini, Italy.
Nivedita AgarwalScientific Institute, IRCCS E. Medea, Diagnostic Imaging and Neuroradiology Unit, Bosisio Parini, Italy.
Rosario MontirossoScientific Institute, IRCCS E. Medea, 0-3 Center for the at-Risk Infant, Bosisio Parini, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Neurodevelopmental disorders (NDs) are a range of heterogeneous clinical conditions associated with dysfunctional brain development. Variations in DNA methylation (DNAm) have been reported in patients with NDs. Piezo1, which is encoded by the Methods: Results: A principal component analysis (PCA) was run and yielded two factors: principal component1 (PC1) comprising 7 CpG sites and principal component2 (PC2) comprising 8 CpG sites. In PC2, DNAm levels were lower in infants with NDs compared to TD, suggesting hypomethylation in the clinical group, which, in turn, might impact the degree of Piezo1 protein expression. Conclusion: We speculate that

Indexed as

DNA methylationepigeneticsneurodevelopmental disordersPiezo1PIEZO1

Identifiers

PMID40823415
PMCPMC12351385

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.