ArticleChemistry of materials : a publication of the American Chemical Society2025
Hyaluronic Acid-Functionalized Highly Porous Polymeric Materials for Stem Cell Culture.
Article in Chemistry of materials : a publication of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe the synthesis of a functional macroporous polymer material and its potential use as a scaffold to support the 3D culture of hematopoietic stem and progenitor cells (HSPCs). Glycidyl methacrylate (GMA)-based emulsion-templated porous polymers (known as polyHIPEs) were prepared by photopolymerization and subsequently surface functionalized with hyaluronic acid (HA) using Huisgen azide-alkyne cycloaddition click reaction, inferring a high degree of functionalization based on the near-quantitative nature of the reactions. Quantitative azidation of GMA-based polyHIPEs is achieved by the ring opening reaction of epoxide rings with sodium azide. Reductive amination reaction is used to end-cap HA with alkyne functionality to be later clicked onto the azidified polyHIPE surfaces. The synthesized polyHIPE materials are characterized by
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Registered trials
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