Evidence map›Paper›PMID 40823388›Full record

ArticleChemistry of materials : a publication of the American Chemical Society2025

Membrane-Inserting α‑Lipid Polymers: Understanding Lipid Membrane Insertion and Effect on Membrane Fluidity.

Lorenzo Schiazza, Gokhan Yilmaz, Pavel Gershkovich, Vivien Yeh, Boyan Bonev, Charles Laughton, Snow Stolnik, Giuseppe Mantovani

Abstract read
In one paragraph

Article in Chemistry of materials : a publication of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A Cholesterol Analogue for Cell-Surface Enzyme Display.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lorenzo SchiazzaSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K.
Gokhan YilmazDepartment of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.
Pavel GershkovichSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K.ORCID https://orcid.org/0000-0003-3136-0933
Vivien YehBiodiscovery Institute and School of Life Sciences, University of Nottingham, Nottingham NG7 2RD, U.K.
Boyan BonevBiodiscovery Institute and School of Life Sciences, University of Nottingham, Nottingham NG7 2RD, U.K.ORCID https://orcid.org/0000-0001-7156-2412
Charles LaughtonSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K.ORCID https://orcid.org/0000-0003-4090-3960
Snow StolnikSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K.
Giuseppe MantovaniSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K.ORCID https://orcid.org/0000-0002-0837-0351

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membrane-inserting materials bearing a lipid residue at one end of their macromolecular chain, α-lipid polymers, are increasingly utilized in biological and pharmaceutical fields. Insertion of these materials into lipid membranes underlines several clinically available liposomal formulations and led to the identification of cellular targets in drug discovery. Herein, we approach this concept from the perspective of a lipid membrane to investigate the relationship between the molecular structure of the inserting α-lipid polymer and the effects that the insertion has on the membrane properties. We synthesized libraries of hydrophilic (co)-polymers comprising neutral or acidic monomers, including

Identifiers

PMID40823388
PMCPMC12355647

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.