Evidence map›Paper›PMID 40823345›Full record

ArticleBiofilm2025

Proteomic identification of PA2146 as a biofilm marker of

Koen van der Ploeg, Corné P de Vogel, Corné H W Klaassen, Theo M Luider, Lona Zeneyedpour, Bibi C G C Mason-Slingerland, Margreet C Vos, Marco J Bruno, Michiel L Bexkens, Juliëtte A Severin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biofilm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. UnderstandingMicroorganisms · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Koen van der PloegDept. of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Corné P de VogelDept. of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands.
Corné H W KlaassenDept. of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands.
Theo M LuiderClinical and Cancer Proteomics, Dept. of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Lona ZeneyedpourClinical and Cancer Proteomics, Dept. of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Bibi C G C Mason-SlingerlandDept. of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands.
Margreet C VosDept. of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands.
Marco J BrunoDept. of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Michiel L BexkensDept. of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands.
Juliëtte A SeverinDept. of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Study background and aims: Methods: Three genetically unrelated Results: MALDI-TOF MS revealed distinct time- and strain-specific spectral profiles, with two notable peaks at approximately 2723 m/z and 5450 m/z. LC-MS/MS identified the 5450 m/z peak as PA2146, corresponding to a 5449.1 Da protein after in vivo methionine cleavage. The 2723 m/z peak was confirmed as its doubly charged ion. Both peaks were absent in strains naturally lacking PA2146, confirming it as the source. Conclusion: PA2146 expression increases during

Indexed as

Bacterial proteinsBiofilmsBiomarkersDisinfectionDuodenoscopesEndoscopyGastrointestinalInstrument contaminationMass spectrometryMatrix-assisted laser desorption-ionization (MALDI-TOF MS)Microbial contaminationProteomicsPseudomonas aeruginosa

Identifiers

PMID40823345
PMCPMC12355587

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.