C-reactive protein is associated with pain-type somatic symptoms independent of mental health symptoms in adolescents: Evidence from the ALSPAC study.

J Cooney-Quane, D S Thomas, Y M Nolan, S Dockray

Abstract read

In one paragraph

Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

HIV-associated depression: a translational framework targeting neuroimmune inflammation and psychosocial stress modulation.Frontiers in immunology · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J Cooney-QuaneSchool of Applied Psychology, Cork Enterprise Centre, University College Cork, Cork, Ireland.

D S ThomasSchool of Applied Psychology, Cork Enterprise Centre, University College Cork, Cork, Ireland.

Y M NolanDepartment of Anatomy and Neuroscience, Western Gateway Building, University College Cork, Cork, Ireland.

S DockraySchool of Applied Psychology, Cork Enterprise Centre, University College Cork, Cork, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression and anxiety disorders frequently first present during adolescence, and both conditions are often comorbid with the experience of pain-type somatic symptoms. Moreover, increased concentrations of blood-derived inflammatory markers, such as C-reactive protein (CRP), have been observed in both depression and anxiety. Altered neuroimmune activation may impact on pain signalling pathways in the nervous system, potentially playing a role in the relationship between mental health and pain-type somatic symptoms. This study conducted cross-sectional secondary data analyses of the Avon Longitudinal Study of Parents and Children (ALSPAC) dataset, using a sample of 2877 participants at age 18. Baron and Kenny's (1986) mediation framework was used to explore whether CRP acts as a mediator between depression and anxiety scores, and pain-type somatic symptoms. While CRP cannot be said to directly mediate the relationship in this sample, adjusted regression analysis found that CRP was a significant, independent predictor of pain-type somatic symptoms (

Indexed as

AdolescenceAnxietyDepressionMental healthPsychoneuroimmunologySomatic pain symptomsSystemic inflammation

Identifiers

PMID40823322

DOI10.1016/j.bbih.2025.101082

PMCPMC12356028

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.