Evidence map›Paper›PMID 40823319›Full record

ArticleBrain, behavior, & immunity - health2025

Maternal immune activation alters infant attentional processing in a nonhuman primate model.

J A Hubbard, S Chen, A M Iosif, A M Ryan, T Murai, C E Hogrefe, T A Lesh, J Smucny, R J Maddock, C M Schumann and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Maternal immune activation in mice recapitulates features of attention-deficit/hyperactivity disorder (ADHD) in susceptible offspring.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

J A HubbardCalifornia National Primate Research Center, University of California Davis, California, 95616, USA.
S ChenDepartment of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, 95817, USA.
A M IosifDepartment of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, 95817, USA.
A M RyanCalifornia National Primate Research Center, University of California Davis, California, 95616, USA.
T MuraiCalifornia National Primate Research Center, University of California Davis, California, 95616, USA.
C E HogrefeCalifornia National Primate Research Center, University of California Davis, California, 95616, USA.
T A LeshDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA, 95817, USA.
J SmucnyDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA, 95817, USA.
R J MaddockDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA, 95817, USA.
C M SchumannThe MIND Institute, School of Medicine, University of California Davis, Sacramento, CA, 95817, USA.
T D HanksDepartment of Neurology, School of Medicine, University of California Davis, Sacramento, CA, 95817, USA.
J Van de WaterDepartment of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California Davis, Sacramento, CA, 95817, USA.
A K McAllisterCenter for Neuroscience, University of California Davis, Davis, CA, 95618, USA.
C S CarterCenter for Neuroscience, University of California Davis, Davis, CA, 95618, USA.
A PauknerDepartment of Comparative Psychology, Nottingham Trent University, Nottingham, UK.
J P CapitanioCalifornia National Primate Research Center, University of California Davis, California, 95616, USA.
M D BaumanCalifornia National Primate Research Center, University of California Davis, California, 95616, USA.

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
UC Davis Conte Center: Neuroimmune Mechanisms of Psychiatric DisordersP50MH106438 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARTER, CAMERON S. · 2015 to 2025
$26.1M
NIH HHS P51 OD011107NIMH NIH HHS P50 MH106438
6 · The paper itself

Abstract

Maternal infection during pregnancy has been linked to the emergence of neurodevelopmental disorders. Preclinical animal models of maternal immune activation (MIA) have provided critical mechanistic links between maternal cytokines and alterations in offspring brain and behavioral development. While most preclinical work on MIA used rodent models, nonhuman primate (NHP) models have strong translational potential due to their greater similarity with humans. Previous NHP MIA models have replicated rodent findings of atypical offspring behavior emerging as animals mature, but few studied MIA-induced alterations in infancy. Here, we present a unique contribution on early milestones of attention in males using a rhesus monkey NHP MIA model. During an assessment of imitation conducted at 1 week-old, MIA-exposed offspring deviated from species-typical abilities to imitate social signals from human demonstrators. During a visual paired comparison task at 1 month, MIA-exposed offspring looked longer at novel abstract stimuli than control animals. A similar response was observed at 3-4 months when MIA-exposed offspring looked longer at novel monkey faces than control animals. The atypical response to novel social stimuli exhibited by MIA-exposed offspring appears contingent on how different the novel stimuli looked compared to the familiar stimuli, where MIA animals looked longer at easy discriminations compared to control animals. These results indicate that attentional processes in MIA-exposed offspring may be disrupted early in development, potentially resulting in longer visual stimuli processing times. Disruption of early attentional processes in the NHP MIA model may provide translational insights to identify children impacted by gestational exposure to maternal infections.

Indexed as

Early developmentImitationMIA modelNeurodevelopmental disordersRhesus macaqueVisual paired comparison

Identifiers

PMID40823319
PMCPMC12356000

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.