ArticleFrontiers in neurology2025
Association between uric acid to high-density lipoprotein cholesterol ratio and moderate-to-severe perivascular spaces burden: a retrospective cross-sectional study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Perivascular spaces (PVS) are critical for waste clearance in the central nervous system and are implicated in various neurological disorders. The uric acid to high-density lipoprotein cholesterol ratio (UHR) is a novel inflammatory-metabolic marker, but its association with PVS burden remains unexplored. This study investigated the association between UHR and moderate-to-severe PVS burden. Methods: A retrospective cross-sectional analysis was conducted on 808 patients between 2022 and 2024. UHR levels were calculated and categorized into quartiles. PVS burdens in the basal ganglia and centrum semiovale regions were assessed. Logistic regression, correlation, subgroup, and restricted cubic splines analyses were performed to evaluate the relationship between UHR and PVS burden. The net reclassification index (NRI) and integrated discrimination improvement (IDI) were calculated. Additionally, sensitivity analyses were performed to validate the robustness of the findings. Results: UHR was significantly higher in patients with moderate-to-severe PVS burden compared to those with none-to-mild PVS burden ( Conclusion: Our findings indicate a significant association between UHR levels and moderate-to-severe PVS burden, demonstrating potential implications for PVS risk assessment and management.
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