Evidence map›Paper›PMID 40823220›Full record

ReviewFrontiers in public health2025

The impact of maternal systemic diseases on the occurrence of cleft lip and palate in newborns: a narrative review.

Hao Sui, Meijun Du, Jiali Chen, Renjie Yang, Bing Shi, Hanyao Huang, Yan Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hao Sui *State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Meijun Du *State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Jiali ChenState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Renjie YangState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Eastern Clinic, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Bing ShiState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Hanyao HuangState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Yan WangState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cleft lip and palate (CLP) is a prevalent congenital anomaly of the maxillofacial region, characterized by abnormal openings in the lip or palate. This condition, affecting approximately 1 in 700 newborns globally, can manifest as cleft lip only, cleft palate only, or both. The etiology of CLP remains multifactorial, involving genetic and environmental influences, with maternal systemic diseases during pregnancy emerging as significant risk factors. Conditions such as circulatory disorders, endocrine and metabolic disorders, infectious diseases, and autoimmune diseases have been associated with increased CLP incidence. These maternal health issues can disrupt normal embryonic development, leading to cleft formation and affecting the child's overall wellbeing, including feeding, speech, dental health, and psychological state. This review explores the relationship between maternal systemic diseases, including circulatory, endocrine and metabolic, infectious, and autoimmune disorders, and the occurrence of CLP in newborns. Understanding these connections is crucial for improving maternal health during pregnancy and reducing the risk of CLP, highlighting the importance of early monitoring and intervention.

Indexed as

Cleft LipCleft PalateMaternal ExposurePregnancy ComplicationsPrenatal Exposure Delayed EffectsFemaleHumansIncidenceInfant, NewbornPregnancyRisk FactorsCLPmaternalpregnancyrisk factorssystemic diseases

Identifiers

PMID40823220
PMCPMC12354372

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.