Evidence map›Paper›PMID 40823182›Full record

ArticleOpen medicine (Warsaw, Poland)2025

Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer.

Wugang Zhu, Wenjing Xu, Degan Liu, Lei Wan, Xiaolan Lu

Abstract read
In one paragraph

Article in Open medicine (Warsaw, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wugang ZhuDepartment of Oncology, The Affiliated Xinghua People's Hospital, Medical School of Yangzhou University, Xinghua, China.
Wenjing XuDepartment of Oncology, The Affiliated Xinghua People's Hospital, Medical School of Yangzhou University, Xinghua, China.
Degan LiuDepartment of Oncology, The Affiliated Xinghua People's Hospital, Medical School of Yangzhou University, Xinghua, China.
Lei WanDepartment of Oncology, The Affiliated Xinghua People's Hospital, Medical School of Yangzhou University, Xinghua, China.
Xiaolan LuDepartment of Critical Care Medicine, The Affiliated Xinghua People's Hospital, Medical School of Yangzhou University, 419 South Yingwu Road, Xinghua, 225700, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to assess the clinical effectiveness and safety of combining immunotherapy with chemotherapy for non-small cell lung cancer. Methods: A comprehensive search of studies published until January 2024 was conducted. Quality assessment was performed using the NOS scale, and a meta-analysis was carried out with RevMan 5.4.1 software. Heterogeneity was assessed using the Results: Out of 1,061 sources, 11 met the inclusion criteria. The meta-analysis indicated that the combination treatment significantly improved 1-year overall survival, objective response rate, and disease control rate compared to chemotherapy alone ( Conclusion: The combination of chemotherapy and immunotherapy exhibits the potential to enhance both survival rates and clinical effectiveness, without the concomitant rise in severe adverse reactions.

Indexed as

combination chemotherapyimmunotherapymeta-analysisnon-small cell lung cancer

Identifiers

PMID40823182
PMCPMC12355367

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.