ArticleOpen medicine (Warsaw, Poland)2025
Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head.
Article in Open medicine (Warsaw, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Identifying coagulation-related biomarkers in steroid-induced osteonecrosis of the femoral head: implications for early diagnosis and treatment.Clinical and experimental medicine · 2026Article
- Immunomodulation in the repair of osteonecrosis of the femoral head: reprogramming strategies for macrophages and immune cells.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to identify candidate diagnostic biomarkers for steroid-induced osteonecrosis of the femoral head (SONFH). Two datasets were downloaded from the Gene Expression Omnibus for analyses of differentially expressed genes (DEGs) and lipid scores in SONFH and control groups and a weighted gene co-expression network analysis. Overlap between genes in the disease-related module, DEGs, and lipid metabolism-related genes was evaluated to obtain lipid metabolism-related DEGs. A diagnostic model was constructed and evaluated using a nomogram analysis and calibration curves. Correlations between immune cells and lipid metabolism-related DEGs in the model were evaluated. In total, 1,724 DEGs were screened between the SONFH and control groups. Seven SONFH-related modules and 18 lipid metabolism-related DEGs were identified. A total of six optimized genes,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.