Evidence map›Paper›PMID 40823172›Full record

ArticleJHEP reports : innovation in hepatology2025

Restoration of the gut-microbiota-liver axis after hepatitis C virus eradication.

Takako Inoue, Jiro Nakayama, Hiroshi Mori, Masaru Tanaka, Daisuke Nakagawa, Masaya Ohnishi, Yui Funatsu, Kei Moriya, Hideto Kawaratani, Hisayoshi Watanabe and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. The Role ofInternational journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Takako InoueDepartment of Clinical Laboratory Medicine, Nagoya City University Hospital, Nagoya, Japan.
Jiro NakayamaLaboratory of Microbial Technology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
Hiroshi MoriAdvanced Genomics Center, National Institute of Genetics, Mishima, Japan.
Masaru TanakaLaboratory of Microbial Technology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
Daisuke NakagawaLaboratory of Microbial Technology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
Masaya OhnishiDepartment of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Yui FunatsuLaboratory of Microbial Technology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
Kei MoriyaDepartment of Gastroenterology and Hepatology, Nara Medical University, Kashihara, Japan.
Hideto KawarataniDepartment of Gastroenterology and Hepatology, Nara Medical University, Kashihara, Japan.
Hisayoshi WatanabeDepartment of Gastroenterology and Hepatology, Tohoku Central Hospital of the Mutual Aid Association of Public School Teachers, Yamagata, Japan.
Goki SudaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Yasuteru KondoDepartment of Hepatology, Sendai Kousei Hospital, Sendai, Japan.
Tatsuya IdeDivision of Gastroenterology, Kurume University Medical Center, Kurume, Japan.
Satoru KakizakiDepartment of Clinical Research, NHO Takasaki General Medical Center, Takasaki, Japan.
Satoshi MiumaDepartment of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Atsushi SuetsuguDepartment of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Kazuhito KawataHepatology Division, Department of Internal Medicine II, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Takao WatanabeDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Japan.
Etsuko IioDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Rie MomodaLaboratory of Microbial Technology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
Yutaka SuzukiDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Akira SakamakiDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Tsunamasa WatanabeDivision of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki, Japan.
Takehisa WatanabeDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Katsuya NagaokaDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Yoichi HiasaDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Japan.
Shuji TeraiDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Hitoshi YoshijiDepartment of Gastroenterology and Hepatology, Nara Medical University, Kashihara, Japan.
Atsushi ToyodaAdvanced Genomics Center, National Institute of Genetics, Mishima, Japan.
Ken KurokawaAdvanced Genomics Center, National Institute of Genetics, Mishima, Japan.
Yasuhito TanakaDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & Aims: We previously reported altered intestinal environmental features during HCV infection. Here, we aimed to characterize the gut-microbiota-liver axis in patients with chronic hepatitis C after a sustained virological response (SVR). Methods: A total of 174 patients with HCV infection were enrolled in a cross-sectional study: 95 with chronic hepatitis (CH-HCV group) and 79 with cirrhosis or hepatocellular carcinoma (LC/HCC-HCV group). In addition, 75 post-SVR patients were included (CH-SVR group, n = 29; LC/HCC-SVR group, n = 46), along with 23 healthy individuals. A longitudinal study was subsequently conducted on 49 patients (CH, n = 29; LC/HCC, n = 20) with SVR at 24 and 48 weeks after the end of treatment. RNA sequencing was performed on 65 patients with HCV infection, 28 post-SVR patients, and 12 healthy controls. Results: In the cross-sectional analysis, HCV eradication was associated with partial restoration of the dysbiotic gut microbiota, including reduced streptococcal overgrowth and an increase in the potentially beneficial genus Conclusion: The gut-microbiota-liver axis is partially restored following HCV eradication, with recovery from liver damage associated with the resurgence of commensal Lachnospiraceae species. Impact and implications: This study offers significant insights into the gut-microbiota-liver axis in patients with chronic hepatitis C following a sustained virological response. The findings demonstrate that HCV eradication promotes partial restoration of the dysbiotic gut microbiota, particularly an increase in the beneficial genus

Indexed as

Blautiachronic hepatitis C (CHC)gut dysbiosismetabolomic analysistranscriptional analysis (RNA-Seq)

Identifiers

PMID40823172
PMCPMC12355056

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