ArticleFrontiers in oncology2025
Global, regional, and national larynx cancer burden and health inequality analysis from 1990 to 2021 with a prediction from 2022 to 2040.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early Detection of Glottic Cancer Through Machine Learning and Acoustic Voice Analysis: A Systematic Review.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Trends and projections of high body mass index-associated non-hodgkin lymphoma burden (1990-2040): A global burden of disease 2021 analysis.Annals of hematology · 2026Article
- The neck matters: optimising lymph node management in laryngeal cancer.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026Review
- Survival outcomes of low-dose and high-dose bevacizumab front-line maintenance in advanced high-grade serous ovarian cancer: a propensity score-matched real-world study.Frontiers in oncology · 2026Article
- Concurrent chemoradiotherapy vs. total laryngectomy in locally advanced laryngeal squamous cell carcinoma: a propensity score-matched retrospective cohort study.American journal of cancer research · 2026Article
- Frontier and Inequality Analyses of the Global Burden of Ectopic Pregnancy: Insights from the GBD 2021.International journal of women's health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: To assess the global burden and health inequalities of laryngeal cancer from 1990 to 2021 and to project future trends up to 2040. Methods: Using the 2021 Global Burden of Disease (GBD) data, this study analyzed trends in prevalence (ASPR), incidence (ASIR), mortality (ASDR), and disability-adjusted life years (DALYs) of laryngeal cancer from 2009 to 2021, with annual percentage change (EAPC) estimates. Inequalities were assessed using the Slope Index of Inequality (SII) and Concentration Index (CI), while future projections to 2040 were made using the Bayesian Age-Period-Cohort (BAPC) model. Results: In 2021, there were approximately 1.1 million global laryngeal cancer cases (an age-standardized prevalence rate (ASPR) of 12.56 per 100,000, 95% UI: 11.76-13.49). The age-standardized incidence rate (ASIR), the age-standardized mortality rate (ASDR), and disability-adjusted life years (DALYs) rates were 2.29, 1.35, and 35.8 per 100,000, respectively. Significant disparities were observed across regions and SDI levels: high SDI regions had the highest incidence rates, while middle-low SDI regions experienced the greatest mortality and DALY burden. Central Europe had the highest ASPR, ASIR, and DALY rates, while the Caribbean reported the highest ASDR. From 1990 to 2021, the DALYs Slope Index of Inequality (SII) dropped from 37.75 (95% CI: 26.92-48.58) to -11.57 (95% CI: -22.14 to -1.00), indicating improved equity in health outcomes between high- and low-income countries. Conclusions: While the global burden of laryngeal cancer is projected to decline by 2040, significant health disparities persist. Addressing these inequalities will require sustained efforts, including equitable resource allocation, improved access to healthcare, and targeted public health interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.