ReviewFrontiers in oncology2025
Advances in research on RNA methylation and cancer radiotherapy resistance.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
RNA methylation is a type of reversible chemical modification in epitranscriptomics that influences gene expression by dynamically regulating RNA functions. RNA methylation comprises N6-methyladenosine (m6A), 5-methylcytosine (m5C), N7-methylguanosine (m7G), N1-methyladenosine (m1A), and 3-methylcytosine (m3C) modifications. These are dynamically controlled by a tripartite enzymatic system: methyltransferases ("writers") add methyl groups, demethylases ("erasers") remove them, and RNA-binding proteins ("readers") recognize and interpret the modifications to mediate downstream biological effects. Extensive research has shown the importance of RNA methylation in the onset and progression of cancer. RNA methylation contributes to radioresistance in cancer cells through various mechanisms, affecting therapeutic outcomes. To date, the precise functions of RNA methylation in cancer radioresistance remain unclear. This review summarizes recent advances in m6A, m5C, m7G, and m1A methylation in cancer radioresistance regulation and discusses the clinical potential of precision therapeutic strategies targeting these methylation modifications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.