Evidence map›Paper›PMID 40823085›Full record

ArticleFrontiers in oncology2025

Pre-operative T-stage discrimination in gallbladder cancer using machine learning and DeepSeek-R1.

Joongwon Chae, Zhenyu Wang, Duanpo Wu, Lian Zhang, Alexander Tuzikov, Magrupov Talat Madiyevich, Min Xu, Dongmei Yu, Peiwu Qin

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Joongwon ChaeInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China.
Zhenyu WangInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China.
Duanpo WuSchool of Communication Engineering and the Artificial Intelligence Institute, Hangzhou Dianzi University, Hangzhou, Zhejiang, China.
Lian ZhangThe First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Alexander TuzikovUnited Institute of Informatics Problems, National Academy of Sciences of Belarus, Minsk, Belarus.
Magrupov Talat MadiyevichDepartment of Biomedical Engineering & Tashkent State Technical University, Tashkent, Uzbekistan.
Min XuAffiliated Fifth Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Dongmei YuAffiliated Fifth Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Peiwu QinInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gallbladder cancer (GBC) frequently exhibits non-specific early symptoms, delaying diagnosis. This study (i) assessed whether routine blood biomarkers can distinguish early T stages via machine learning and (ii) compared the T-stage discrimination performance of a large language model (DeepSeek-R1) when supplied with (a) radiology-report text alone versus (b) radiology-report text plus blood-biomarker values. Methods: We retrospectively analyzed 232 pathologically confirmed GBC patients treated at Lishui Central Hospital between 2023 and 2024 (T1, Results: Biomarker-based machine-learning models yielded uniformly poor T-stage discrimination. Without SMOTE, individual models such as XGBoost achieved an AUROC of 0.508 on the independent test set, while recall for the T1 class remained low (e.g., 14.3% for some models), indicating performance near random chance. Applying SMOTE to the training data produced statistically significant gains in cross-validation (CV) accuracy for several models (e.g., XGBoost CV Acc. 0.71 → 0.80, Conclusions: The evaluated blood biomarkers did

Indexed as

biomarkerDeepSeek-R1gallbladder cancerGBClarge language modelmachine learningradiology reportstaging

Identifiers

PMID40823085
PMCPMC12355213

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.