Evidence map›Paper›PMID 40823035›Full record

ArticleFrontiers in nutrition2025

Mehtap Kara, Gozde Hasbal-Celikok, Jacob Wilson, Pilar Gómez-Serranillos, Tugba Yilmaz-Ozden, Ezgi Öztas, Gul Özhan, Özge Sultan Zengin, Marta Sánchez Gómez-Serranillos, Claudia Owsianik and 10 more

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Health Benefits of a StandardizedFood science & nutrition · 2026
    Article
  2. Frontiers in nutrition · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mehtap KaraDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Türkiye.
Gozde Hasbal-CelikokDepartment of Biochemistry, Faculty of Pharmacy, Istanbul University, Istanbul, Türkiye.
Jacob WilsonApplied Science & Performance Institute, Tampa, FL, United States.
Pilar Gómez-SerranillosDepartment of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Complutense, University of Madrid, Madrid, Spain.
Tugba Yilmaz-OzdenDepartment of Biochemistry, Faculty of Pharmacy, Istanbul University, Istanbul, Türkiye.
Ezgi ÖztasDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Türkiye.
Gul ÖzhanDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Türkiye.
Özge Sultan ZenginDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Türkiye.
Marta Sánchez Gómez-SerranillosDepartment of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Complutense, University of Madrid, Madrid, Spain.
Claudia OwsianikDepartment of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Complutense, University of Madrid, Madrid, Spain.
Fazle RabbaniDepartment of Psychiatry, Lady Reading Hospital, Peshawar, Pakistan.
Merve TunçDepartment of Molecular Biology and Genetics, Institute of Graduate Studies in Sciences, Istanbul University, Istanbul, Türkiye.
Nazlı ArdaDepartment of Molecular Biology and Genetics, Faculty of Science, Istanbul University, Istanbul, Türkiye.
Nazia M MemonDepartment of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Ikram UjjanDepartment of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Kenny HawkinsApplied Science & Performance Institute, Tampa, FL, United States.
Justine DavisApplied Science & Performance Institute, Tampa, FL, United States.
Gabriel WilsonApplied Science & Performance Institute, Tampa, FL, United States.
Giovanna PetrangoliniMedical Department, Indena SpA, Milan, Italy.
Amjad KhanDepartment of Biochemistry, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Low mood and cognitive impairments are multifactorial conditions often linked to oxidative stress, neurotransmitter imbalances, and neuroinflammation. Bilberry ( Aims of the study: This study aimed to comprehensively evaluate the biochemical, antioxidant, and neuroprotective properties of a standardized bilberry extract (Mirtoselect™), alongside assessing its potential health benefits on mood and cognitive enhancement in a clinical setting. Methods: Results: Bilberry extract demonstrated significant inhibition of GABA-T, MAO-A, and AChE, alongside moderate GABA Conclusion: Bilberry extract exhibits potent antioxidant, neuromodulatory, and neuroprotective properties, supporting its potential as a natural intervention for managing low mood and cognitive health. The favorable safety profile and preliminary clinical benefits warrant further research.

Indexed as

AChEBilberry extractcognitionGABA-TMAO-AMirtoselectTMmood

Identifiers

PMID40823035
PMCPMC12352346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.