ReviewFrontiers in nutrition2025
An easily overlooked cause of pulmonary arterial hypertension-thiamine deficiency.
Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Dietary thiaminase alters morphology and decreases swimming performance of lake trout (Salvelinus namaycush).Scientific reports · 2026Article
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Authors and funding
4 authors.
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Abstract
Thiamine deficiency (TD), also known as vitamin B1 deficiency, is an often overlooked potential cause of pulmonary arterial hypertension (PAH). It may contribute to the pathological process of PAH through the deficiency of related coenzymes, thereby inhibiting the citric acid cycle. TD can manifest in various clinical forms, including dry beriberi and Shoshin beriberi, the latter characterized by high-output heart failure and lactic acidosis, which can lead to fatal outcomes if not promptly treated. This article reviews the physiological functions of thiamine, the pathophysiological mechanisms of TD, and its relationship with PAH. It explores the hemodynamic changes and diagnostic challenges of Shoshin beriberi and highlights the potential value of thiamine supplementation therapy. Although large-scale randomized controlled trials are currently lacking, minor studies and case reports suggest that thiamine supplementation may benefit PAH patients. Future high-quality research is needed to clarify the role of thiamine in the treatment of PAH.
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