ArticleFrontiers in nutrition2025
Influence of oropharyngeal therapy with mother's own milk on the microbiome and metabolome of very preterm infants: a pilot study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oropharyngeal therapy with mother's own milk (OPT-MOM) may serve as a promising therapeutic approach to elicit immunoprotective and anti-inflammatory benefits for preterm infants. Objectives: This prospective pilot study aims to investigate whether OPT-MOM alters the oral microbiota, gut microbiota and metabolic profiles in very preterm infants. Methods: The eligible infants were divided into two groups: the OPT-MOM group and the control group. The OPT-MOM group received oropharyngeal administration with mother's own milk every 3 h, starting within the first 48 h after birth and lasted for 14 days. Salivary samples and fecal samples from both groups were collected to detect microbes using 16S rRNA gene sequencing, while fecal metabolomics was measured by untargeted liquid chromatograph-mass spectrometer. Results: A total of 26 very preterm infants were enrolled in the study, with 13 assigned to each group. Our study identified distinct oral and intestinal microbiome profiles in OPT-MOM group compared to the control group. Briefly, the relative abundance of the Escherichia-Shigella and Enterobacter genera was significantly reduced in the oral cavity of preterm infants in the OPT-MOM group, while the abundance of the Rothia genus increased markedly. After 14 days of intervention, the gut microbiota of preterm infants in the OPT-MOM group exhibited a significant decrease in the abundance of the Proteobacteria phylum and a concomitant increase in the abundance of the Firmicutes phylum, which emerged as the dominant phylum. Additionally, the OPT-MOM group showed a significant increase in the relative abundance of Streptococcus and Staphylococcus genus, while a significant decrease in Enterococcus and Enterobacter genus abundance was observed in the gut microbiota. The predominant bacteria in the oral microbiota of preterm infants are highly similar to those in the intestinal microbiota. Metabolomic profiling identified that the OPT-MOM group demonstrated significantly higher levels of multiple potentially beneficial metabolites, including N-acetylneuraminic acid, myristoylcarnitine, lauroylcarnitine, acetylcarnitine, and 2,4-dihydroxybutanoic acid. Conclusion: Administration of OPT-MOM could promote the establishment of favorable microbial communities in both oral and intestinal ecosystems of preterm infants, potentially facilitating the production of metabolites that are crucial for infant health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.