ArticleJournal of oral biology and craniofacial research
Evaluation of the cytotoxicity, apoptotic effects, and remineralization potential of recent bioceramic-based root canal sealers.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Oxidative Stress, Pro-Inflammatory Response, Cytotoxicity and Apoptosis Induced by Contemporary Endodontic Sealers in Human Periodontal Ligament Fibroblasts.Journal of functional biomaterials · 2026Article
- Comparative analysis between resin-based root canal sealer and recent bioceramic-based root canal sealers using MicroCT, film thickness, and solubility.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study is aimed at evaluating the cytotoxicity, apoptosis/necrosis, and calcium ion release of ADseal (a resin-based sealer) and two recently introduced bioceramic-based root canal sealers, which are VDW.1 seal bioceramic and Fill Root ST. Methods: The cellular responses were studied in human periodontal ligament stem cells (hPDLSCs). Four root canal sealer extracts concentrations (100 %, 50 %, 25 %, and 12.5 %) were assessed for cell viability using the cell viability MTT essay and after 24 h, 48 h, and 7 days for all concentrations. To determine the effect of materials on apoptosis and necrosis, flow cytometry analysis was used. Calcium ion release was evaluated after 14 days of storage in distilled water using optical emission spectroscopy (ICP-OES). A two-way ANOVA was used for the statistical analysis of the acquired results. Results: Fill Root ST and VDW.1 seal bioceramic showed the highest amount of cell viability compared to ADseal sealer. Moreover, Fill Root ST, followed by VDW.1 seal bioceramic, demonstrated decreased cell apoptosis and necrosis. Moreover, VDW.1 seal bioceramic showed the highest calcium ion release, followed by Fill Root ST. ADseal sealers showed the lowest calcium ion release compared to bioceramic-based root canal sealers. Conclusions: Based on the results of this study, in terms of cytotoxicity, apoptosis/necrosis, and remineralization ability, bioceramic-based root canal sealers were more biocompatible than ADseal resin-based sealers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.