Evidence map›Paper›PMID 40822942›Full record

ArticleFrontiers in endocrinology2025

Cardiac structure and function recovery in acromegaly after treatment: insights from cardiac magnetic resonance imaging.

Yu Chen, Yangjie Li, Yu Tang, Jing Li, Yerong Yu, Huiwen Tan, Bowen Cai, Shu Jiang, Wei Wang, Songping Zheng and 5 more

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Exercise ModulatesInternational journal of molecular sciences · 2026
    Article
  2. Acromegaly complications: an update.The Journal of clinical endocrinology and metabolism · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yu Chen *Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yangjie Li *Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yu TangDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jing LiDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yerong YuDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Huiwen TanDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Bowen CaiDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Shu JiangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Wei WangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Songping ZhengDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Peizhi ZhouDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yi WeiDepartment of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jiayu SunDepartment of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yucheng ChenDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jianwei LiDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Cardiac magnetic resonance imaging (CMRI) provides a detailed method for understanding the specific cardiovascular alterations associated with acromegaly. This study aimed to evaluate the impact of personalized treatment on cardiac structure, function, and myocardial tissue characteristics using CMRI, and to assess the effects of biochemical remission on improving cardiovascular complications in acromegaly patients. Method: Thirty-nine acromegaly patients were enrolled from July 2020 to February 2023 at West China Hospital of Sichuan University. Comprehensive cardiac assessments were conducted using a 3.0 T MRI scanner at baseline and one year after individualized treatment. Results: Among the 30 patients who completed both baseline and one-year follow-up CMRI examinations, significant reductions in left ventricular (LV) wall thickness and end-diastolic diameter were observed compared to baseline (both Conclusion: Patients with acromegaly exhibited LV hypertrophy, enlargement, myocardial fibrosis and impaired systolic function assessed by CMRI compared with healthy controls. Individualized treatment led to partial reversed of these abnormalities, particularly in those who achieved biochemical remission.

Indexed as

AcromegalyHeartMagnetic Resonance ImagingRecovery of FunctionAdultFemaleFollow-Up StudiesHeart VentriclesHumansMagnetic Resonance Imaging, CineMaleMiddle AgedMyocardiumacromegalycardiac functioncardiac magnetic resonance imagingheart structuremyocardial lesions

Identifiers

PMID40822942
PMCPMC12350105

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.