Evidence map›Paper›PMID 40822935›Full record

ArticleAI in neuroscience2025

DeepLabCut to Automate Behavioral Analysis of Parkinsonism.

Nabeel Rangoonwala, Khoi Le, Vaibhavi Peshattiwar, Caroline Swain, Dipesh Pokharel, Tatiana White, Thyagarajan Subramanian, Kala Venkiteswaran

Abstract read
In one paragraph

Article in AI in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nabeel RangoonwalaNeurology, University of Toledo, Toledo, Ohio, USA.
Khoi LeNeurology, University of Toledo, Toledo, Ohio, USA.
Vaibhavi PeshattiwarNeurology, University of Toledo, Toledo, Ohio, USA.
Caroline SwainNeurology, University of Toledo, Toledo, Ohio, USA.
Dipesh PokharelNeurology, University of Toledo, Toledo, Ohio, USA.
Tatiana WhiteNeurology, University of Toledo, Toledo, Ohio, USA.
Thyagarajan SubramanianNeurology, University of Toledo, Toledo, Ohio, USA.
Kala VenkiteswaranNeurology, University of Toledo, Toledo, Ohio, USA.

Funding

Gut-brain axis in Parkinson's diseaseR01DK124098 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI BROWNING, KIRSTEEN NAIRN, SUBRAMANIAN, THYAGARAJAN · 2020 to 2025
$2.6M
Optogenetic and Chemogenetic Dissection of Cell TransplantsR01NS104565 · NINDS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI SUBRAMANIAN, THYAGARAJAN · 2018 to 2022
$1.8M
NIDDK NIH HHS R01 DK124098NINDS NIH HHS R01 NS104565
6 · The paper itself

Abstract

Background: Behavioral assessment of parkinsonism often relies on human rater evaluation. However, human biases and variability necessitate larger sample sizes to maintain validity, leading to extensive video analysis and limiting researchers' time. Recent artificial intelligence (AI) and machine learning (ML) advancements enable efficient data analysis, offering unbiased decision-making and consistency across scenarios, bridging inter-rater differences. While not fully automating jobs, AI/ML boosts productivity when properly trained with diverse data. This study aims to show that AI/ML can assist in the analysis of rat parkinsonian behavioral studies to reduce labor dependence while still maintaining accuracy. Methods: DeepLabCut (DLC), an animal pose estimation software, was used to analyze motor behavior in video recordings of parkinsonian Sprague Dawley rats while they performed the stepping test ( Results: There was good absolute agreement between the two scoring methods, using the two-way random effect model, kappa = 0.9,

Indexed as

animal behaviorartificial intelligenceDeepLabCutmachine learningParkinson’s

Identifiers

PMID40822935
PMCPMC12356275

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.