Evidence map›Paper›PMID 40822933›Full record

ReviewMaterials today. Bio2025

Conductive polymers in smart wound healing: From bioelectric stimulation to regenerative therapies.

Yanhua Jiang, Yongjian Zhou, Yu Tian, Noushin Nabavi, Milad Ashrafizadeh, João Conde, Zhe Li, Liang Guo

Abstract readReview
In one paragraph

Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Advancements in Functional Polymeric Scaffolds for Scar-Free Skin Regeneration.Polymer science & technology (Washington, D.C.) · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Multi-hierarchical biofunctional polymeric biomaterial to promote wound closure.Journal of materials science. Materials in medicine · 2026
    Article
  7. Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.Journal of biomedical materials research. Part B, Applied biomaterials · 2026
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yanhua JiangDepartment of Anesthesiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Yongjian ZhouDepartment of Anesthesiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Yu TianScience Research Center, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Noushin NabaviIndependent Researcher, Victoria, V8V 1P7, British Columbia, Canada.
Milad AshrafizadehDepartment of Radiation Oncology, Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250000, Shandong, China.
João CondeComprehensive Health Research Centre (CHRC), NOVA Medical School, Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, Lisboa, Portugal.
Zhe LiDepartment of Anesthesiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Liang GuoDepartment of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing, particularly in particularly after surgical operations and especially cardiothoracic surgeries, presents a significant global healthcare burden due to prolonged recovery time, recurrent infections, and limited effectiveness of the conventional therapies. The recent advancements in biomaterials have positioned conductive polymers (CPs) as promising components in the design of next-generation wound care technologies. CPs, such as polypyrrole (PPy), polyaniline (PANI) and poly (3,4-ethylenedioxythiophene) (PEDOT), possess unique electrical, chemical and biological properties, making them ideal for integration into multifunctional and responsive wound dressings. The present review focuses on the emerging role of CPs in wound healing, along with their incorporation into various delivery platforms including hydrogels, nanofibers, membranes, microneedle patches and 3D scaffolds. These materials provide a synergistic approach by enabling localized electrical stimulation, enhancing tissue regeneration, and producing antibacterial, antioxidant and anti-inflammatory effects. In particular, it is discussed how CP-based systems can be engineered to respond dynamically to the wound microenvironment such as pH, temperature or enzymatic activity, for accelerating controlled drug release and real-time therapeutic intervention. It also highlights the integration of CPs with complementary technologies such as triboelectric nanogenerators, biosensors and photothermal agents, contributing to smarter, more personalized wound care solutions. Moreover, this review addresses the current challenges, including biocompatibility, degradation kinetics and scalability, with a summary of the directions for the future research to optimize clinical translation. Based on the recent findings across materials science, bioengineering and regenerative medicine, this review illustrates the transformative potential of CPs in advancing effective, non-invasive and patient-specific wound healing strategies.

Indexed as

Cardiothoracic surgeriesConductive polymersElectrical stimulationSmart dressingsTissue regenerationWound healing

Identifiers

PMID40822933
PMCPMC12355517

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.