Evidence map›Paper›PMID 40822905›Full record

ArticleCurrent behavioral neuroscience reports2024

The Relationship Between Vitamin D and the Development and Treatment of Attention-Deficit Hyperactivity Disorder: An Overview of Systematic Reviews.

Razi Kitaneh, Laya Jalilian-Khave, Binah Baht Ysrayl, Anna Borelli, Melissa C Funaro, Marc N Potenza, Gustavo A Angarita

Abstract read
In one paragraph

Article in Current behavioral neuroscience reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Razi KitanehDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Laya Jalilian-KhaveDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Binah Baht YsraylDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Anna BorelliDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Melissa C FunaroHarvey Cushing/John Hay Whitney Medical Library, Yale University, New Haven, CT, USA.
Marc N PotenzaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Gustavo A AngaritaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.

Funding

Neuroimaging Sciences Training ProgramT32DA022975 · NIDA · YALE UNIVERSITY · PI Graeme F Mason, Rajita Sinha · 2007 to 2026
$5.7M
Vitamin D Modulation of Midbrain Dopamine Function: A 11C-PHNO PET Study in Healthy HumansR01AT010508 · NCCIH · YALE UNIVERSITY · PI POTENZA, MARC N · 2019 to 2020
$1.7M
NCCIH NIH HHS R01 AT010508NIDA NIH HHS T32 DA022975
6 · The paper itself

Abstract

Purpose of Review: This review explores the role of vitamin D in the pathophysiology and management of attention-deficit/hyperactivity disorder (ADHD). Given the localization of Vitamin D receptors in brain regions implicated in ADHD and vitamin D's role in neurotransmitter regulation, this review synthesizes research that examines vitamin D's relationship to the development and therapeutic outcomes of ADHD. Recent Findings: A systematic literature search resulted in the selection of seven reviews meeting the inclusion criteria. These reviews summarize original studies that are focused on: 1. The association between prenatal Vitamin D levels and ADHD in offspring, with meta-analyses suggesting that higher maternal serum Vitamin D levels reduce the likelihood and severity of ADHD symptoms in children. 2. Comparative analyses of Vitamin D levels in children with ADHD versus those without, showing lower Vitamin D levels in affected children. 3. Intervention studies where Vitamin D supplementation was linked to improvements in ADHD symptoms. Results: Seven reviews met the inclusion criteria, from which the main results were: 1. Meta-analyses suggested a decreased risk of offspring with ADHD and fewer or less severe ADHD-related features later in life with higher maternal serum Vitamin D levels. 2. Children with ADHD were found to have lower serum Vitamin D levels than children without ADHD across the original literature. 3. Vitamin D supplementation was associated with improvements in ADHD symptoms. Summary: The literature supports relationships between Vitamin D levels and ADHD, both in its emergence and clinical management. Despite these findings, further research is indicated. There remains a need for additional well-powered randomized clinical trials to provide evidence and guide clinical practice regarding the use of Vitamin D in ADHD and to ensure that interventions are efficacious, well tolerated and tailored to individual patients.

Indexed as

ADHDNeurodevelopmentPrenatal Vitamin D levelsSystematic reviewsVitamin DVitamin D supplementation

Identifiers

PMID40822905
PMCPMC12356127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.