Evidence map›Paper›PMID 40822881›Full record

ArticleNanoscale advances2025

A novel nanocomposite Lf-DA-MSN-PF127 aided the delivery of dopamine for the treatment of Parkinson's disease in a rat model.

Ramesha Hanumanthappa, Sumit Ramesh Naik, Sahana Prakash Nayak, Asmatanzeem Bepari, Hanan Nasser Altamimi, Mujeeb Ahmed Shaikh, Fahd A Nasr, Farha M Shaikh, P C Nethravathi, Hemalatha Nanjaiah and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ramesha HanumanthappaNeurochemistry Lab, Department of Biochemistry, Karnatak University Dharwad Karnataka-580003 India ksdevaraju@kud.ac.in.ORCID https://orcid.org/0000-0003-2768-2753
Sumit Ramesh NaikNeurochemistry Lab, Department of Biochemistry, Karnatak University Dharwad Karnataka-580003 India ksdevaraju@kud.ac.in.
Sahana Prakash NayakNeurochemistry Lab, Department of Biochemistry, Karnatak University Dharwad Karnataka-580003 India ksdevaraju@kud.ac.in.
Asmatanzeem BepariDepartment of Basic Health Sciences, College of Medicine, Princess Nourah bint Abdulrahman University Riyadh 11671 Saudi Arabia.
Hanan Nasser AltamimiDepartment of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University Al-Kharj 11942 Saudi Arabia.
Mujeeb Ahmed ShaikhDepartment of Basic Medical Science, College of Medicine, Al-Maarefa University Diriyah 13713 Riyadh Saudi Arabia.ORCID https://orcid.org/0000-0001-7843-2784
Fahd A NasrDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh 11623 Saudi Arabia.
Farha M ShaikhDepartment of Basic Medical Science, College of Medicine, Al-Maarefa University Diriyah 13713 Riyadh Saudi Arabia.
P C NethravathiDepartment of Chemistry, University College of Science, Tumkur University Tumkur Karnataka 572103 India.
Hemalatha NanjaiahNeurochemistry Lab, Department of Biochemistry, Karnatak University Dharwad Karnataka-580003 India ksdevaraju@kud.ac.in.
D SureshDepartment of Chemistry, University College of Science, Tumkur University Tumkur Karnataka 572103 India.ORCID https://orcid.org/0000-0002-0505-1830
Raghu S VDivision of Neuroscience, Yenepoya Research Centre (YRC), Yenepoya (Deemed to be University) Mangalore Karnataka-575018 India.ORCID https://orcid.org/0000-0001-5537-1405
Kuramkote Shivanna DevarajuNeurochemistry Lab, Department of Biochemistry, Karnatak University Dharwad Karnataka-580003 India ksdevaraju@kud.ac.in.ORCID https://orcid.org/0000-0002-6199-354X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dopamine is a pivotal neurotransmitter in the central nervous system, which is instrumental in motor functions. Parkinson's Disease (PD) is a chronic, progressive, age-related neurodegenerative disorder marked by the progressive loss of dopaminergic neurons in the pars compacta of the

Identifiers

PMID40822881
PMCPMC12356145

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.