Evidence map›Paper›PMID 40822859›Full record

ArticleNon-coding RNA research2025

LncRNA

Mohammad Ahmad, Lucie Thorel, Emilie Brotin, Edwige Abeilard, Monique N'Diaye, Shéhérazade Sebda, Jean-Pascal Meneboo, Martin Figeac, Benoît Bernay, Laurent Poulain and 3 more

Abstract read
In one paragraph

Article in Non-coding RNA research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mohammad AhmadUniversité de Caen Normandie, Inserm, Anticipe UMR 1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, SF 4207 Normandie Oncologie, Normandie Univ, F-14000, Caen, France.
Lucie ThorelUniversité de Caen Normandie, Inserm, Anticipe UMR 1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, SF 4207 Normandie Oncologie, Normandie Univ, F-14000, Caen, France.
Emilie BrotinUniversité de Caen Normandie, ImpedanCELL Core Facility, Service Unit PLATON, F-14000, Caen, France.
Edwige AbeilardUniversité de Caen Normandie, Inserm, Anticipe UMR 1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, SF 4207 Normandie Oncologie, Normandie Univ, F-14000, Caen, France.
Monique N'DiayeUniversité de Caen Normandie, Inserm, Anticipe UMR 1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, SF 4207 Normandie Oncologie, Normandie Univ, F-14000, Caen, France.
Shéhérazade SebdaUniv. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UAR 2014 - PLBS, F-59000, Lille, France.
Jean-Pascal MenebooUniv. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UAR 2014 - PLBS, F-59000, Lille, France.
Martin FigeacUniv. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UAR 2014 - PLBS, F-59000, Lille, France.
Benoît BernayProteogen platform, Normandie Univ, UNICAEN, Caen, France.
Laurent PoulainUniversité de Caen Normandie, Inserm, Anticipe UMR 1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, SF 4207 Normandie Oncologie, Normandie Univ, F-14000, Caen, France.
Louis-Bastien WeiswaldUniversité de Caen Normandie, Inserm, Anticipe UMR 1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, SF 4207 Normandie Oncologie, Normandie Univ, F-14000, Caen, France.
Christophe DenoyelleUniversité de Caen Normandie, Inserm, Anticipe UMR 1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, SF 4207 Normandie Oncologie, Normandie Univ, F-14000, Caen, France.
Matthieu Meryet-FiguièreUniversité de Caen Normandie, Inserm, Anticipe UMR 1086, Interdisciplinary Research Unit for Cancer Prevention and Treatment, SF 4207 Normandie Oncologie, Normandie Univ, F-14000, Caen, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian carcinoma (OC) exhibits a 5-year survival rate of below 40 %, mainly due to late-stage diagnosis and recurrence associated to resistance to chemotherapy. Long noncoding RNAs (lncRNAs) are involved in numerous cellular processes of critical physiological relevance and dysregulation of their expression has been implicated in various pathologies, including cancer. However, the functions and mechanisms of the majority of them remains largely uncharacterized. To investigate their potential roles in treatment response, we performed RNA sequencing (RNA-Seq) on 47 High Grade Serous Ovarian Carcinoma (HGSOC) samples, including 28 from patients who achieved a complete response to first-line therapy and 19 from those with partial response or stable disease. Among the differentially expressed transcripts, we identified

Indexed as

lncRNAsMICAL2Migration and invasionMYO16-AS1Ovarian cancerPatient-derived tumor organoids

Identifiers

PMID40822859
PMCPMC12351189

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.