Evidence map›Paper›PMID 40822788›Full record

ArticleBioinformation2025

Periapical healing in endodontic retreatment: A comparative study of nano-hydroxyapatite with and without PRF.

Shelly Singh, Jnana Ranjan Swain, Megha Gugnani, Ashtha Arya, Ranjita Singh Baghel, Samra Shafique

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shelly SinghDepartment of Dental Surgery, School of Dental Medicine, University of Colorado, USA.
Jnana Ranjan SwainDepartment of Pedodontics and Preventive Dentistry, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
Megha GugnaniDepartment of Conservative and Endodontics, Yamuna Institute of Dental Sciences and Research, Gadhauli, Yamunanagar, Haryana, India.
Ashtha AryaDepartment of Conservative Dentistry and Endodontics, SGT Dental College, Hospital and Research Institute, SGT University, Gurugram, Haryana- 122505, India.
Ranjita Singh BaghelDepartment of Periodontics, Index Institute of Dental Sciences, Indore, Madhya Pradesh, India.
Samra ShafiqueDepartment of Conservative Dentistry and Endodontics, Sardar Patel Postgraduate Institute of Dental and Medical Sciences, Raibareli Rd, Utrathia, Vrindavan Colony, Lucknow, Uttar Pradesh 226025, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy of nano-hydroxyapatite (nHA) alone and in combination with platelet-rich fibrin (PRF) in enhancing periapical bone healing following endodontic retreatment is of interest. Thirty-two patients with failed endodontic treatment in anterior teeth were divided into two groups. After retreatment, apicoectomy and root-end filling with mineral trioxide aggregate (MTA) were performed. Group 1 received nHA alone, while Group 2 received a combination of nHA and PRF in the periapical cavity. Follow-ups at 1, 3, and 6 months showed significant lesion size reduction in both groups, with faster healing in the nHA+PRF group at 1 month, but no long-term differences.

Indexed as

bone healingnano-hydroxyapatitenano-hydroxyapatite (nHA)Periapical pathosisPlatelet-Rich Fibrin (PRF)retreatment

Identifiers

PMID40822788
PMCPMC12357677

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.