ArticleThe World Allergy Organization journal2025
The clinical characteristics and inflammatory endotypes of chronic rhinosinusitis with nasal polyps in Southern China: A multi-center, cross sectional study.
Article in The World Allergy Organization journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of Life-Context Factors on Chronic Rhinosinusitis 22-Item Sinonasal Outcomes Test: Systematic Review + Meta-Analysis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Pooled it
- The Association Between Allergic Rhinitis, Eosinophilic Inflammation, and Postoperative Recurrence in Nasal Polyps.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Severe Chronic Rhinosinusitis with Nasal Polyps: From IL-5-Driven Pathogenetic Mechanisms to Clinical Management in the Italian Clinical Setting.Journal of inflammation research · 2026Review
- Comments on "Clinical-cytological grading: An integrated approach to stratifying CRSwNP beyond eosinophilia".The World Allergy Organization journal · 2025Article
- Chronic rhinosinusitis with and without nasal polyps: the state-of-the-art of current treatment strategies and future developments.Frontiers in allergy · 2025Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a prevalent inflammatory disease characterized by prolonged symptoms and frequent recurrences. According to clinical and pathological characteristics, patients can be classified into different endotypes. Limited data exist on the endotype distribution of CRSwNP in Southern China. Objective: This study aimed to delineate the clinical characteristics and inflammatory endotypes of CRSwNP in Southern China, with a focus on the impact of asthma and allergic comorbidities on disease severity and recurrence. Methods: This multi-center, cross-sectional study analyzed 375 adult patients with CRSwNP from 3 hospitals in Southern China. Patients were classified into type 2 and non-type 2 endotypes based on clinical criteria, including blood eosinophil counts, serum immunoglobulin E levels, and tissue eosinophil percentages. Data on demographics, clinical symptoms, comorbidities, and histopathological features were collected. Statistical analyses identified factors associated with disease severity and recurrence. Results: Among the 375 patients, 75.7% had type 2 CRSwNP. Patients with type 2 CRSwNP, particularly those with asthma, had more severe symptoms and lower quality of life scores than those with non-type 2 CRSwNP. Allergic rhinitis (AR) was associated with a higher risk of recurrence but not with disease severity. Middle-aged and older patients were more likely to exhibit type 2 features and asthma as a comorbidity. Conclusions: Type 2 CRSwNP is predominant in Southern China, with significant implications for disease management. The presence of asthma as a comorbidity exacerbates symptoms and reduces quality of life. AR as a comorbidity was not relevant to the severity of CRSwNP.
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