Evidence map›Paper›PMID 40822709›Full record

ArticleFrontiers in computational neuroscience2025

Exploring subthreshold processing for next-generation TinyAI.

Farid Nakhle, Antoine H Harfouche, Hani Karam, Vasileios Tserolas

Abstract read
In one paragraph

Article in Frontiers in computational neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Farid NakhleDepartment of Computer Science, Temple University, Japan Campus, Tokyo, Japan.
Antoine H HarfoucheUnité de Formation et de Recherche en Sciences Économiques, Gestion, Mathématiques, et Informatique, Université Paris Nanterre, Nanterre, France.
Hani KaramDepartment of Computer Science, Temple University, Japan Campus, Tokyo, Japan.
Vasileios TserolasDepartment of Computer Science, Temple University, Japan Campus, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The energy demands of modern AI systems have reached unprecedented levels, driven by the rapid scaling of deep learning models, including large language models, and the inefficiencies of current computational architectures. In contrast, biological neural systems operate with remarkable energy efficiency, achieving complex computations while consuming orders of magnitude less power. A key mechanism enabling this efficiency is subthreshold processing, where neurons perform computations through graded, continuous signals below the spiking threshold, reducing energy costs. Despite its significance in biological systems, subthreshold processing remains largely overlooked in AI design. This perspective explores how principles of subthreshold dynamics can inspire the design of novel AI architectures and computational methods as a step toward advancing TinyAI. We propose pathways such as algorithmic analogs of subthreshold integration, including graded activation functions, dendritic-inspired hierarchical processing, and hybrid analog-digital systems to emulate the energy-efficient operations of biological neurons. We further explore neuromorphic and compute-in-memory hardware platforms that could support these operations, and propose a design stack aligned with the efficiency and adaptability of the brain. By integrating subthreshold dynamics into AI architecture, this work provides a roadmap toward sustainable, responsive, and accessible intelligence for resource-constrained environments.

Indexed as

dendritic processingenergy efficiencygraded activationshybrid analog-digital systemsneuromorphic computingsubthreshold processingsustainable AI designTinyAI

Identifiers

PMID40822709
PMCPMC12351320

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.