Evidence map›Paper›PMID 40822666›Full record

ArticleTherapeutic advances in infectious disease

A composite vignette: xylazine, infectious complications and the importance of community-based drug checking services.

Liam John, Nathaniel Flint, Francesca Piccolo, Katherine Hill, Marion Anderson, Brian Townsend, Michael Fletcher, Cole Altomare-Jarczyk, Kristen Silvia, Traci Green and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Liam JohnMaineHealth Maine Medical Center, Portland, ME, USA.
Nathaniel FlintColby College, Department of Chemistry, Waterville, ME, USA.
Francesca PiccoloMaineHealth Institute for Research, Portland, ME, USA.
Katherine HillYale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, USA.
Marion AndersonChurch of Safe Injection, Lewiston, ME, USA.
Brian Townsendcommonspace, Portland, ME, USA.
Michael FletcherMaine Access Points, Brunswick, ME, USA.
Cole Altomare-JarczykBrandeis University, Opioid Policy Research Collaborative, Heller School for Social Policy and Management, Waltham, MA, USA.
Kristen SilviaMaineHealth Maine Medical Center, Portland, ME, USA.
Traci GreenBrandeis University, Opioid Policy Research Collaborative, Heller School for Social Policy and Management, Waltham, MA, USA.
Dasan ThamattoorColby College, Department of Chemistry, Waterville, ME, USA.
Jean BessetteMaineHealth Institute for Research, Portland, ME, USA.
Kinna ThakararMaineHealth Maine Medical Center, 41 Donald B Dean Drive, Suite B, South Portland, ME 04106, USA MaineHealth Institute for Research, Portland, ME, USA.ORCID https://orcid.org/0000-0003-4689-0240

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we describe a composite vignette of a patient who developed necrotic wounds and systemic infection after reported exposure to xylazine, a veterinary anesthetic found as an adulterant in the unregulated drug supply. While exposure to xylazine-containing compounds via the use of fentanyl is not a new phenomenon, xylazine's prevalence in overdose deaths has escalated, and its geographic distribution has expanded to include rural areas such as Maine. We use this composite vignette to highlight: (1) the growing number of overdoses in Maine where xylazine was found in combination with fentanyl, (2) the potential severe, infection-related complications of xylazine exposure, and (3) describe novel harm reduction strategies that utilize community- and laboratory-based drug checking technology.

Indexed as

bacteremiacase reportpublic healthxylazine

Identifiers

PMID40822666
PMCPMC12357011

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.