Evidence map›Paper›PMID 40822598›Full record

ArticleJournal of mood and anxiety disorders2025

The structure of posttraumatic stress symptoms in youth with and without obsessive-compulsive disorder: New insights using factor and network analysis.

Caitlin M Pinciotti, Matti Cervin, Kendall N Drummond, Jeffrey D Shahidullah, Justin F Rousseau, Cody G Dodd, Mercedes Ramirez, John M Hettema, Robyn Richmond, Leslie K Taylor and 9 more

Abstract read
In one paragraph

Article in Journal of mood and anxiety disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Caitlin M PinciottiBaylor College of Medicine, Houston, TX, USA.
Matti CervinBaylor College of Medicine, Houston, TX, USA.
Kendall N DrummondBaylor College of Medicine, Houston, TX, USA.
Jeffrey D ShahidullahUniversity of Texas at Austin, Austin, TX, USA.
Justin F RousseauUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.
Cody G DoddUniversity of Texas Medical Branch, Galveston, TX, USA.
Mercedes RamirezUT Health San Antonio, San Antonio, TX, USA.
John M HettemaTexas A&M University, Bryan, TX, USA.
Robyn RichmondTexas Tech University Health Sciences Center, Lubbock, TX, USA.
Leslie K TaylorUniversity of Texas Health Sciences Center, Houston, TX, USA.
Lynn MonnatUniversity of Texas at Austin, Austin, TX, USA.
Leslie ProchUniversity of North Texas, Denton, TX, USA.
Fei TengUniversity of Texas at Austin, Austin, TX, USA.
Wayne K GoodmanBaylor College of Medicine, Houston, TX, USA.
Eric A StorchBaylor College of Medicine, Houston, TX, USA.
Andrew G GuzickBaylor College of Medicine, Houston, TX, USA.
D Jeffrey NewportUniversity of Texas at Austin, Austin, TX, USA.
Karen Dineen WagnerUniversity of Texas Medical Branch, Galveston, TX, USA.
Charles B NemeroffUniversity of Texas at Austin, Austin, TX, USA.

Funding

Prediction of Alcohol Use Disorder and PTSD After Trauma in AdolescentsR01AA029090 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI CHARLES B NEMEROFF · 2022 to 2026
$4.4M
NIAAA NIH HHS R01 AA029090
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) and obsessive-compulsive disorder (OCD) share ostensibly similar and sometimes overlapping symptoms that complicate diagnostic assessment and conceptualization. While varying models for the symptom structure of PTSD have been proposed - including the presently used 4-factor and a more fine-grained 7-factor model - little research has focused on youth and even less is known about how these symptoms relate to one another when OCD is present. The present study used confirmatory factor analysis (CFA) and network analysis to compare PTSD symptom relations among 2066 trauma-exposed youth aged 8-20 enrolled in the Texas Childhood Trauma Research Network, of which 10.9 % met diagnostic criteria for OCD. CFA model fit was strongest for the 7-factor PTSD model, and multigroup CFA found no evidence that the structure differed as a function of OCD diagnosis, sex, nor age group. Internal consistency in the 7-factor model ranged from poor to good (α = 0.59-0.80), while all clusters of the 4-factor model demonstrated adequate internal consistency (α = 0.75-0.89). Network analysis revealed unique associations between PTSD and OCD. Specifically, having OCD was linked to more Negative Affect (edge = 0.15) and Anhedonia (edge = 0.16), which are both part of the 4-factor Negative Alterations in Cognitions and Mood symptom cluster. While the clinical relevance of the 7-factor model is still unclear, it evidenced mixed empirical support in the present sample and provided greater nuance when examining links between PTSD and OCD.

Indexed as

Multigroup confirmatory factor analysisNetwork analysisObsessive-compulsive disorderPosttraumatic stress disorderTrauma exposure

Identifiers

PMID40822598
PMCPMC12351679

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.