Evidence map›Paper›PMID 40822555›Full record

ArticleNature photonics2025

Trionic All-optical Biological Voltage Sensing via Quantum Statistics.

Yundong Ren, Chawina De-Eknamkul, Fengyi Sun, Mehrdad Ramezani, Gisselle Gonzalez, Wenzhuo Huang, Jake H Schwab, Madison Wilson, Adam J Engler, Duygu Kuzum and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature photonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Bioelectricity, Moving On….Bioelectricity · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yundong RenDepartment of Chemical and Nano Engineering, University of California San Diego; La Jolla, California 92093, United States.
Chawina De-EknamkulDepartment of Chemical and Nano Engineering, University of California San Diego; La Jolla, California 92093, United States.
Fengyi SunDepartment of Electrical and Computer Engineering, University of California San Diego; La Jolla, California 92093, United States.
Mehrdad RamezaniDepartment of Electrical and Computer Engineering, University of California San Diego; La Jolla, California 92093, United States.
Gisselle GonzalezShu Chien-Gene Lay Department of Bioengineering, University of California San Diego; La Jolla, CA, 92093, United States.
Wenzhuo HuangDepartment of Electrical and Computer Engineering, University of California San Diego; La Jolla, California 92093, United States.
Jake H SchwabDepartment of Chemical and Nano Engineering, University of California San Diego; La Jolla, California 92093, United States.
Madison WilsonDepartment of Electrical and Computer Engineering, University of California San Diego; La Jolla, California 92093, United States.
Adam J EnglerShu Chien-Gene Lay Department of Bioengineering, University of California San Diego; La Jolla, CA, 92093, United States.
Duygu KuzumDepartment of Electrical and Computer Engineering, University of California San Diego; La Jolla, California 92093, United States.
Ertugrul CubukcuDepartment of Chemical and Nano Engineering, University of California San Diego; La Jolla, California 92093, United States.

Funding

Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
Mechanogenetics: An Integrated Approach to Aging in Muscle DysfunctionR01AG045428 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ENGLER, ADAM J · 2013 to 2022
$3.4M
E-Organoids: Functional Brain Organoids Co-grafted with Transparent MicrothreadsDP2EB030992 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUZUM, DUYGU · 2020 to 2020
$2.4M
Neuro-flakes: Direct Voltage Imaging of Neural Activity with Atomically-thin Optoelectronic MaterialsR21EY033676 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CUBUKCU, ERTUGRUL · 2022 to 2024
$576k
An Ultra High-Density Virtual Array with Nonlinear Processing of Multimodal Neural RecordingsR21EY029466 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUZUM, DUYGU · 2018 to 2019
$455k
Multimodal Probing of Neural Activity Using Transparent Microelectrode ArraysR21EB026180 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUZUM, DUYGU · 2018 to 2019
$433k
NEI NIH HHS R21 EY029466NEI NIH HHS R21 EY033676NHLBI NIH HHS T32 HL007444NIA NIH HHS R01 AG045428NIBIB NIH HHS DP2 EB030992NIBIB NIH HHS R21 EB026180
6 · The paper itself

Abstract

Quantum confinement in monolayer semiconductors results in optical properties intricately linked to electrons, which can be manipulated by external electric fields. These optoelectronic features offer untapped potential for studying biological electrical activity. In addition to their relatively high quantum yields, picosecond level emission lifetimes make these materials particularly promising for monitoring biological voltages with high spatiotemporal resolution. To this end, we investigate exciton to trion conversion in angstrom thick semiconductors to experimentally demonstrate label-free, dual-polarity, all-optical detection of electrical activity, via changes in photoluminescence, in cardiomyocyte cultures with ultrahigh temporal resolution. We devise a physical model to elucidate that this conversion process is inherently governed by the quantum statistics of the background electrons induced by biological activity. We show that monolayer MoS

Identifiers

PMID40822555
PMCPMC12352334

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.