Evidence map›Paper›PMID 40822520›Full record

ArticleFood science & nutrition2025

Tea Polyphenol Modulates Mitochondria-Associated Endoplasmic Reticulum Membrane of Hippocampal Neurons Targeting Grp75 to Ameliorate Memory Impairment in the Aged T2DM Rats.

Mengqian Shi, Le Cheng, Chenhui Lv, Wenjuan Feng, Xi Wang, Shuangzhi Chen, Chenyang Li, Lushan Xue, Cheng Zhang, Xuemin Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengqian ShiNutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health and Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University Taiyuan Shanxi People's Republic of China.
Le ChengNutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health and Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University Taiyuan Shanxi People's Republic of China.
Chenhui LvNutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health and Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University Taiyuan Shanxi People's Republic of China.
Wenjuan FengNutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health and Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University Taiyuan Shanxi People's Republic of China.
Xi WangNutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health and Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University Taiyuan Shanxi People's Republic of China.
Shuangzhi ChenNutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health and Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University Taiyuan Shanxi People's Republic of China.
Chenyang LiThe Second Clinical Medical College of Shanxi Medical University Taiyuan Shanxi People's Republic of China.
Lushan XueNutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health and Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University Taiyuan Shanxi People's Republic of China.
Cheng ZhangNutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health and Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University Taiyuan Shanxi People's Republic of China.
Xuemin LiCenter for Disease Control and Prevention in Shanxi Province Taiyuan Shanxi People's Republic of China.
Haifeng ZhaoNutritional and Food Science Research Institute, Department of Nutrition and Food Hygiene, School of Public Health and Center for Ecological Public Health Security of Yellow River Basin Shanxi Medical University Taiyuan Shanxi People's Republic of China.ORCID https://orcid.org/0000-0002-7306-3024

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tea polyphenol (TP), as the most abundant and unique functional substance of tea, has been widely studied for the neuroprotective effects. Previous studies also found that TP improves the memory impairment of the aged T2DM rats, but the underlying molecular mechanism has not been fully clarified. The model of aged T2DM was induced by injecting D-galactose and STZ intraperitoneally, as well as feeding with a high-glucose-fat diet in rats, and D-galactose and D-glucose were used in PC12 cells. Memory function, mitochondrial damage, mitochondria-associated endoplasmic reticulum membrane (MAM), Ca

Indexed as

agedmemorymitochondria‐associated endoplasmic reticulum membraneT2DMtea polyphenol

Identifiers

PMID40822520
PMCPMC12351061

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.