ArticleFrontiers in pharmacology2025
Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Epigenetic Modulation by Luteolin, Quercetin and Apigenin in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Protective effects of curcumin against chemical-induced toxicity in the male reproductive system: a systematic review.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The induction of oxidative stress (OS) in host cells by antibiotics (ATBs) such as ciprofloxacin (CIP) and chloramphenicol (CMP) is associated with their side effects. Flavonoids such as quercetin (Q) and luteolin (LT) could counteract the harmful effects related to OS induced by ATBs. Purpose: The purpose of this research was to investigate the Materials and methods: Q and LT were isolated from Results and discussion: Both ATBs were capable of increasing ROS production in polymorphonuclear cells, and Q and LT were more effective in inhibiting it than vitamin C. Regarding SOD and CAT activity, CIP and CMP altered their activity. Regardless of an increase in enzymatic activity, as in the case of CIP, or a decrease in antioxidant systems, as in the case of CMP, both flavonoids restore enzymatic activity to similar values as those of control cells. Concerning the PO increase observed by CIP and CMP, both Q and LT can prevent it. Finally, the association of flavonoids and ATBs on antimicrobial activity in Conclusion: These
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