Evidence map›Paper›PMID 40822456›Full record

ArticleFrontiers in pharmacology2025

Synergistic antibacterial photodynamic therapy of lysine-porphyrin conjugate and metal ions combination against

Xueming Wang, Zhonghua Qin, Ying Wen, Mingxuan Chi, Lixia Zhang, Junping Wu, Tianjun Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xueming Wang *State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China.
Zhonghua Qin *Tuberculosis Precision Testing Center, Tianjin Haihe Hospital, Tianjin, China.
Ying WenState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China.
Mingxuan ChiState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China.
Lixia ZhangTuberculosis Precision Testing Center, Tianjin Haihe Hospital, Tianjin, China.
Junping WuTuberculosis Precision Testing Center, Tianjin Haihe Hospital, Tianjin, China.
Tianjun LiuState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In previous research, antibacterial photodynamic therapy using lysine-porphyrin conjugate LD Methods: To address this limitation, we developed a synergistic antibacterial strategy by combining LD Results: Synergy was confirmed via minimum inhibitory concentration and fractional inhibitory concentration index analyses, demonstrating 16- to 64-fold enhanced antibacterial efficacy compared to LD Discussion: This study elucidated the enhanced antimicrobial mechanisms and safety of LD

Indexed as

antibacterial photodynamic therapyCandida albicanslysine-conjugated porphyrin compoundmetal ionsMycobacterium tuberculosissynergistic antibacterial therapy

Identifiers

PMID40822456
PMCPMC12350416

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.