ArticleJournal of pain research2025
Corticospinal Excitability in Bilateral M1 Hand Areas: Association with Neuropathic Pain After Spinal Cord Injury.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Motor Cortex rTMS Alleviates Pain and Comorbid Depression After Spinal Cord Injury with a Correlate in M1 Intracortical Inhibition.Journal of pain research · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Neuropathic pain (NP) is a major and debilitating complication of spinal cord injury (SCI), frequently occurring bilaterally below the injury level. Repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex (M1) is suggested as a treatment for NP following SCI (SCI-NP). However, the specific changes in corticospinal excitability (CSE) within the bilateral M1 remain unclear, hindering the development of optimized rTMS parameters for SCI-NP. Patients and Methods: This retrospective study analyzed data from 625 SCI patients and 131 healthy controls. Motor-evoked potential (MEP) was used to assess CSE in the bilateral M1 hand areas. The hemispheric asymmetry of bilateral M1 CSE was measured by calculating the natural logarithm of the MEP amplitude ratio between the dominant hemisphere (DH) and non-dominant hemisphere (NDH), expressed as ln(DH/NDH amplitude). The study utilized correlation analysis and multiple linear regression to examine the associations between hemispheric CSE asymmetry and the course, severity, and emotional disturbances of NP. Results: SCI patients experiencing NP exhibited lower MEP amplitude than those without NP in bilateral M1 hand areas, with a more pronounced decrease in NDH. Hemispheric CSE asymmetry was found to be elevated and positively correlated with NP course (r=0.213, Conclusion: Hemispheric CSE asymmetry shows potential as a biomarker for assessing SCI-NP severity and emotional disturbances in SCI patients. High-frequency rTMS targeting bilateral M1 hand areas may provide improved analgesic effects. This finding could enhance neuropathic pain assessment and guide rTMS optimization, potentially improving the quality of life for individuals with SCI.
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