Evidence map›Paper›PMID 40822410›Full record

ArticleGynecologic oncology reports2025

Growing teratoma syndrome in a chemotherapy naïve patient.

Sarah Werner, Tricia Numan, Peter Frederick, Nicole Gaulin, Katherine Mager, Mohamed Desouki, Emese Zsiros

Abstract readCase Reports
In one paragraph

Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah WernerDepartment of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Tricia NumanDepartment of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Peter FrederickDepartment of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Nicole GaulinDepartment of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Katherine MagerDepartment of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Mohamed DesoukiDepartment of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Emese ZsirosDepartment of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growing Teratoma Syndrome (GTS) is an exceptionally rare condition primarily observed in patients diagnosed with malignant germ cell tumors. It is characterized by the development of enlarging masses during or following the completion of appropriate chemotherapy, with normalization of previously elevated serum tumor markers, and a final pathologic assessment of the masses reveals benign mature teratomatous elements. The underlying mechanism of the benign teratomatous growth remains unclear. Multiple potential routes of dissemination have been proposed, with the peritoneum being the most reported site of metastasis. In this report, we present the case of an adolescent female patient diagnosed with an ovarian grade 1 immature teratoma, who developed disseminated peritoneal and mesenteric implants shortly after her initial surgery. The pathologic review of the implants demonstrated only mature teratomatous elements. Uniquely, the masses were identified in a chemotherapy naïve patient.

Identifiers

PMID40822410
PMCPMC12351119

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.